主要学习及工作经历 1979.9-1983.7 延边大学（211大学）药学院 获医学学士学位； 1986.9-1989.7 沈阳药科大学天然药物化学专业 理学硕士学位； 1995.9-1999.2 韩国Chungbuk国立大学校 获药理学博士学位； 1983.7-1999.2 延边大学 天然药化助教、讲师、副教授；药理学副教授； 1999.2-2000.2 LG生活健康上海天然物研究所 首席科学家/研发部长； 2000.2-2001.2 韩国教育部 BK 21项目组 任退行性疾病的预防及治疗研究组 特聘研究员。 2001.2-2001.5 北京金赛狮生物医药技术开发有限公司 研发总监（CTO） 2001.5-2004.7 北京大学基础医学院药理学系 副教授 2004.8-至今 北京大学基础医学院药理学系 教授

主要学术任职 中国生命科学学会联合体副秘书长；中国药理学会秘书长；中国药理学会教学与科普专业委员会主任委员；中国睡眠研究会睡眠生理与药理专业委员会副主任，中国民族医药学会药理与毒理学分会执行会长；科技部重大项目审评专家；国家自然科学基金审评专家；教育部高校专家；国家科学技术奖励评审专家；《药理学通报》编委、《神经药理学报》编委、Biomolecules & Therapeutics (SCIE)编委、Current Psychopharmacology (Bentham)编委、Remedy OA Journal编委；

获奖情况 第一届中国健康长寿创新大赛二等奖；北京大学仲外医学奖

研究方向 【1】抑郁症、创伤后应激障碍(PTSD)和老年痴呆及睡眠障碍相关疾病动物模型建立及其病理机制研究； 【2】从中药和天然产物中发现具有安神作用的候选药，并进行结构优化—确定候选药物； 【3】新机制新结构 抗抑郁药的临床前研究。

基金来源 [1] 国家自然科学基金 [2] “十一五”国家“重大新药创制”专项候选药项目 [3] “十三五”国家“重大新药创制”专项临床前研究项目 [4] 中国医学科学院中央级公益性科研院所基本科研业务费专项资金

代表论文 1)  Qin Y, Hu X, Zhao HL, Kurban N, Chen X, Yi JK, Zhang Y, Cui SY,Zhang YH* Inhibition of Indoleamine 2,3-Dioxygenase Exerts Antidepressant-like Effects through Distinct Pathways in Prelimbic and Infralimbic Cortices in Rats under Intracerebroventricular Injection with Streptozotocin. Int J Mol Sci. 2024 Jul 8;25(13):7496. doi: 10.3390/ijms25137496.
2) Qin Y, Zhao Y, Hu X, Chen X, Jiang YP, Jin XJ, Li G, Li ZH, Yang JH, Zhang GL, Cui SY, Zhang YH*. Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease. Front Pharmacol. 2024 Apr 24;15:1390294. doi: 10.3389/fphar.2024.1390294
3) Zhao Y, Qin Y, Hu X, Chen X, Jiang YP, Jin XJ, Li G, Li ZH, Yang JH, Cui SY, Zhang YH. Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer's disease. Front Pharmacol. 2024 Apr 24;15:1406127. doi: 10.3389/fphar.2024.1406127.
4) Hu X, Zhao HL, Kurban N, Qin Y, Chen X, Cui SY, Zhang YH*. Reduction of BDNF Levels and Biphasic Changes in Glutamate Release in the Prefrontal Cortex Correlate with Susceptibility to Chronic Stress-Induced Anhedonia. eNeuro 2023, 10(11): ENEURO.0406-23.2023. doi: 10.1523/ENEURO.0406-23.2023.

5) Kurban N, Qin Y, Zhao HL, Hu X, Chen X, Zhao YY, Peng YS, Wang HB, Cui SY, Zhang YH*. Chronic Stress-Induced Elevation of Melanin-Concentrating Hormone in the Locus Coeruleus Inhibits Norepinephrine Production and Associated With Depression-Like Behaviors in Rats. Int J Neuropsychopharmacol. 2024 Jan 1;27(1):pyad069. doi: 10.1093/ijnp/pyad069. PMID: 38135278; PMCID: PMC10799331.

6）Hui Ding, Su-Ying Cui, Xiang-Yu Cui, Yu-Tong Liu, Xiao Hu, Hui-Ling Zhao, Yu Qin, Nurhumar Kurban, Yong-He Zhang*. Anti-stress effects of combined block of glucocorticoid and mineralocorticoid receptors in the paraventricular nucleus of the hypothalamus. Br J Pharmacol 2021 doi: 10.1111/bph.15511.

7) Hui-Ling Zhao, Su-YingCui, YuQin, Yu-Tong Liu, Xiang-Yu Cui, Xiao Hu, Nurhumar Kurban, Ming-Yan Li, Zhen-Hao Li, Jing Xu, Yong-He Zhang∗. Prophylactic effects of sporoderm-removed Ganoderma lucidum spores in a rat model of streptozotocin-induced sporadic Alzheimer's disease. J Ethnopharmacol 2021, https://doi.org/10.1016/j.jep.2020.113725 

8) Su-Ying Cui, Yuan-Li Huang, Xiang-Yu Cui, Hui-Ling Zhao, Xiao Hu, Yu-Tong Liu, Yu Qin, Nurhumar Kurban, Yong-He Zhang*. A common neuronal mechanism of hypertension and sleep disturbances in spontaneously hypertensive rats: Role of orexinergic neurons. Prog Neuropsychopharmacol Biol Psychiatry 100 (2020) 109902. https://doi.org/10.1016/j.pnpbp.2020.109902 

9) Su-Ying Cui, Yuan-Li Huang, Xiang-Yu Cui, Hui-Ling Zhao, Xiao Hu, Yu-Tong Liu, Yong-He Zhang*. The involvement of Serotonin in Alterations of Sleep Homeostasis in Spontaneously Hypertensive Rats. J Sleep Res 2019;00:e12947. https ://doi.org/10.1111/jsr.12947 

10) Xu YP, Cui XY, Liu YT, Cui SY, Zhang YH*. Ginsenoside Rg1 promotes sleep in rats by modulating the noradrenergic system in the locus coeruleus and serotonergic system in the dorsal raphe nucleus. Biomed Pharmacother 2019 Aug;116:109009. doi: 10.1016/j.biopha.2019.109009. 

11) Ye H, Cui XY, Ding H, Cui SY, Hu X, Liu YT, Zhao HL, Zhang YH*. Melanin-concentrating hormone (MCH) and MCH-R1 in the locus coeruleus may be involved in the regulation of depressive-like behavior. Int J Neuropsychopharmacol 2018; doi: 10.1093/ijnp/pyy088. 

12) Cui SY, Song JZ, Cui XY, Hu X, Ma YN, Shi Yu-Tong, Luo Ying, Ge Yan-Ru, Ding H, Ye H, Zhang YH*. Intracerebroventricular streptozotocin-induced Alzheimer’s disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex. CNS Neurosci Ther 2018; 24:1241–1252. https://doi.org/10.1111/cns.13032 

13) Bin Yu, Su-Ying Cui, Xue-Qiong Zhang, Xiang-Yu Cui, Sheng-Jie Li, Zhao-Fu Sheng, Qing Cao, Yuan-Li Huang, Ya-Ping Xu, Zhi-Ge Lin, Guang Yang and Yong-He Zhang*. Mechanisms underlying physiological and psychological stress-induced abrupt awakening from posttraumatic “nightmares”. Int J Neuropsychopharmacol 2016, 19(4): 1-6. (doi: 10.1093/ijnp/pyv113). 

14) Bin Yu, Su-Ying Cui, Xue-Qiong Zhang, Xiang-Yu Cui, Sheng-Jie Li, Zhao-Fu Sheng, Qing Cao, Yuan-Li Huang, Ya-Ping Xu, Zhi-Ge Lin, Guang Yang, Jin-Zhi Song, Hui Ding & Yong-He Zhang*. Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats. Sci Rep 2015 DOi: 10.1038/srep15976. 

 15) Sheng ZF, Cui XY, Cui SY, Yu B, Zhang XQ, Li SJ, Cao Q, Huang YL, Xu YP, Song JZ, Ding H, Lin ZG, Yang G, Zhang YH*. Involvement of adrenoceptors, dopamine receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice. Acta Pharmacol Sin 2015, 36(8):949-956.