主要学习及工作经历 1979.9-1984. 7 山西医科大学医疗系本科生 1988.9-1991.7 中山医科大学硕士研究生 1993.9-1996.10 北京大学医学部生化与分子生物学系博士生 1984.8 -1988. 8 山西长治医学院助教 1991.9-1993.8 山西长治医学院讲师 1996.11-1997.2 山西长治医学院讲师 1997.3-2004.8 Research Fellow, Visiting Fellow, National Institute on Aging, NIH, Baltimore, MD 2004.9-2006.8 Assistant Professor, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 2006.9- 北京大学医学部生物化学与分子生物学系， 教授

主要学术任职 中华老年医学会基础学组， 副组长

获奖情况 2009年中华医学一等奖 （第十完成人）

研究方向 转录后基因调控，细胞衰老

基金来源 国家自然科学基金， 973项目

代表论文 1. Wang W, Furneaux H, Caldwell MC, Hutter C, Holbrook N, Gorospe M. (2000) HuR Regulates p21 mRNA Stabilization by Ultraviolet light. Mol. Cel. Biol. 20:760-769. 2. Wang W, Caldwell MC,Lin S, Furneaux H, Gorospe M. (2000) HuR Regulates Cyclin A and Cyclin B1 mRNA Stability during Cell Proliferation. EMBO J. 19(10):2340-2350. 3. Wang W, Yang X, Cristofalo V, Holbrook N, Gorospe, M. (2001) Loss of HuR is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence. Mol. Cel. Biol. 21(17): 5889-5898. 4. Wang W, Fan J, Yang X, Furer-Galban S, Lopez I, Kobbe C, Guo J, Georas S, Foufelle F, Hardie D, Carking D, Gorospe M. (2002) AMP-Activated Kinase Regulates Cytoplasm HuR, Mol. Cel. Biol. 22 (10): 3425-3436. 5. Wang W, Yang X, Lopez I, Carking D, Gorospe, M. (2003) In creased AMP:ATP Ratio and AMP-activated Protein Kinase Activity during Cellular Senescence Linked to Reduced HuR Function. J. Biol. Chem. 278(29): 27016-27023. 6. Wang W, Yang X, Kawai T, Lopez De Silanes I, Mazan-Mamczarz K, Chen P, Chook Y, Quensel C, Kohler M, Gorospe M. (2004) AMPK-Regulated Acetylation and Phosphorylation of Importin-a1: Involvement in the Nuclear Import of RNA-binding Protein HuR. J. Biol. Chem. 279(46): 48376-48388. 7. Wang, W., Yang, X., Martindale, J., and Gorospe, M.: AUF1-Mediated mRNA Turnover is Responsible for Up-regulation of p16 during Replicative Senescence. EMBO Rep. 6 (2): 158-164, 2005. 8 Ma L, Chang N, Guo S, Zhang Z, Wang W, Tong, T. (2008) CSIG Regulates PTEN Translation in Replicative Senescence. Mol. Cel. Biol. 28(20):6290-6301. Correspondence Author 9. Yi J, Chang N, Liu X, Guo G, Xue L,Tong T, Gorospe M, and Wang W. (2010). Reduced Nuclear Export of HuR mRNA by HuR Is Linked to the Loss of HuR in Replicative Senescence. Nucleic Acids Res. 38(5):1547-58. 10. Guo G, Ma L, Jiang B, Yi J, Tong T, and Wang W. (2010). Hydrogen peroxide induces p16INK4 through an AUF1-dependent manner. J. Cell. Biochem. 109(5):1000-1005. 11. Na Chang, Jie Yi, Gaier Guo, Xinwen Liu, Yongfeng Shang, Tanjun Tong, Qinghua Cui, Ming Zhan, Myriam Gorospe, and Wengong Wang. HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay. Mol. Cell. Biol. published ahead of print on 24 May 2010, doi:10.1128/MCB.00169-10.