主要学习及工作经历 1994.08—1999.05　　美国宾夕法尼亚州立大学 博士 1999.05—2001.05　 美国哈佛大学医学院 博士后 2001.06—2002.04 美国哈佛大学医学院 讲师 2002.04— 北京大学医学部 “长江学者”特聘教授

主要学术任职 中国科学院院士 《Journal of Biological Chemistry》编委（Editorial Board）

获奖情况 光华工程科技奖青年奖 何梁何利科学与技术进步奖 中国青年科技奖

研究方向 主要从事基因转录调控的表观遗传机制和乳腺癌/子宫内膜癌发生发展的分子机理的研究。

基金来源 国家自然科学基金创新研究群体项目一项，国家自然科学基金点项目一项，科技部“973”计划项目两项。

代表论文 1. Yongfeng Shang, Xiao Hu, James Direnzo, Mitch Lazar, and Myles Brown (2000). Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103: 843-852 2. Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua Yu, Jing Liang, Luyang Sun, Xiaohan Yang, Lei Shi, Ruifang Li, Qian Li, Xia Yi, and Yongfeng Shang* (2009). LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 138: 660-672 3. Huijian Wu, Yupeng Chen, Jing Liang, Bin Shi, Ge Wu, Ying Zhang, Dan Wang, Ruifang Li, Xia Yi, Hua Zhang, Luyang Sun, and Yongfeng Shang* (2005). Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature 438: 981-987 4. Yongfeng Shang and Myles Brown (2002). Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468 5. Yongfeng Shang* (2006). Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nature Reviews Cancer 6: 360-368 (invited review) 6. Yongfeng Shang, Molly Myers and Myles Brown (2002). The formation of androgen receptor transcription complex. Molecular Cell 9: 601-610 7. Hua Zhang, Xia Yi, Xiaojing Sun, Na Yin, Bin Shi, Huijian Wu, Dan Wang, Ge Wu, and Yongfeng Shang* (2004). Differential gene regulation by the SRC family of coactivators. Genes and Development 18: 1753-1765 8. Luyang Sun, Lei Shi, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang* (2009). JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Proc Natl Acad Sci U S A. 106: 10195-10200 9. Xin Li, Jing Liang, Haijing Yu, Bing Su, Chunjie Xiao, Yongfeng Shang*, Wen Wang* (2007). Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics 23: 427-431 10. Ruifang Li , Hua Zhang , Wenhua Yu , Yupeng Chen , Bin Gui , Jing Liang , Yan Wang , Luyang Sun , Xiaohan Yang , Yu Zhang , Lei Shi , Yanyan Li, and Yongfeng Shang* (2009). ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. The EMBO Journal 28: 2763–2776