主要学习及工作经历 1999年获北京大学医学部免疫学系硕士学位 2007年获北京大学医学部免疫学系博士学位 1994.6-2010.7 北京大学医学部免疫学系 讲师、副教授 2010.8-至今 北京大学医学部免疫学系 教授

获奖情况 2012年获北京大学基础医学院SCI优秀论文二等奖，本人为通讯作者 2010年获北京大学基础医学院SCI优秀论文二等奖，本人为通讯作者 2009年获北京大学医学部发明专利奖，本人为第一发明人 2007年获北京大学基础医学院SCI优秀论文三等奖，本人为通讯作者 2006年获北京大学医学部SCI优秀论文三等奖，基础医学院SCI优秀论文二等奖，本人为第一作者 2004年获教育部推荐国家科技二等奖，本人为第四完成人 2003年获北京大学医学部夜大学优秀教师奖 2000年获北京大学医学部优秀教师奖

研究方向 人类新趋化因子的表达、结构、功能和作用机制的研究，及其相关自主创新药物的研发。

基金来源 2026.1-2029.12国家自然科学基金面上项目“PSMP调控代谢功能障碍相关脂肪性肝炎的新机制及其靶向干预研究”  2023.1-2026.12国家自然科学基金面上项目“靶向新靶点调节中性粒细胞促进抗菌免疫的作用和机制及其治疗性抗体的研究”  2020.1-2023.12国家自然科学基金面上项目“损伤诱导新趋化细胞因子PSMP表达及其调控肝纤维化作用的机制研究”  2018.1-2021.12国家自然科学基金面上项目“新趋化细胞因子FAM3D在结肠稳态和炎症中的作用和机制的研究”   2015.1-2018.12国家自然科学基金面上项目“人CCR2新的高亲和力配体PSMP的表达，及其在肝病非可控炎症恶性转化中作用和机制的研究”   2013.1-2016.12国家自然科学基金面上项目“从人类基因组编码基因中发现潜在的新趋化因子，并进行表达、功能、机制的研究” 2012.1-2016.8 973计划“重大心血管疾病相关GPCR新药物靶点的基础研究”（课题骨干） 2011.1-2013.12主持国家自然科学基金面上项目“CMTM8及其变异体在肿瘤细胞上皮间质转化中的作用及机制研究”  2009.1-2010.12主持科技部“重大新药创制”科技重大专项“趋化素样因子1衍生多肽作为候选新药的研究与开发”  2009.1-2011.12主持国家自然科学基金重大研究计划培育项目“针对CKLF1与趋化因子受体的相互作用设计、发现和获取小分子化合物及其炎症干预作用的研究”  2009.1-2011.12主持国家自然科学基金面上项目“CKLF1趋化作用机制的研究”  2007.1-2009.12主持国家自然科学基金面上项目“CMTM8在细胞因子受体转运和信号转导中调控作用的研究”  2003.1-2005.12主持国家自然科学基金面上项目“人趋化素样因子相关蛋白2的结构与功能研究”

代表论文

1.      Zhanming Song#, Weijian Yao#, Xuekang Wang, Yaqian Mo, Zhongtian Liu, Qingqing Li, Lei Jiang, Hui Wang, Huiying He, Ning Li, Zhaohuai Zhang, Ping Lv, Yu Zhang, Li Yang*, Ying Wang*. The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2. Mol Ther. 2024 Jul 3;32(7):2248-63.

2.      Xiaolei Pei#,*, Li Liu#, Jieru Wang#, Changyuan Guo, Qingqing Li, Jia Li, Qian Ren, Runzhi Ma, Yi Zheng, Yan Zhang, Li Liu, Danfeng Zhen, Pingzhang Wang, Ping Jiang, Xiaoming Feng, Er-lie Jiang, Ying Wang*, and Sizhou Feng*. Exosomal secreted SCIMP regulates communication between macrophages and neutrophils in pneumonia. Nat Commun. 2024 Jan 23;15(1):691.

3.      Shiyang Huang#, Can Zheng#, Guoguang Xie#, Zhanming Song, Pingzhang Wang, Yun Bai, Dixin Chen, Yan Zhang, Ping Lv, Weiwei Liang, Shaoping She, Qingqing Li, Zhongtian Liu, Yun Wang, Guogang Xing*, Ying Wang*. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice. Molecular Psychiatry. 2021 Jun;26(6):2363-79.

4.      Weiwei Liang#, Xinjian Peng#, Qingqing Li, Pingzhang Wang, Ping Lv, Quansheng Song, Shaoping She, Shiyang Huang, Keqiang Chen, Wanghua Gong, Wuxing Yuan, Vishal Thovarai, Teizo Yoshimura, Colm O’huigin, Giorgio Trinchieri, Jiaqiang Huang, Shuye Lin, Xiaohong Yao, Xiuwu Bian, Wei Kong, Jianzhong Xi, Ji Ming Wang*, Ying Wang*. FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis. Nat Commun. 2020 Nov 20;11(1) :5912.

5.      Shaoping She#, Xiaoning Wu#, Danfeng Zheng, Xiaolei Pei, Jing Ma, Yameng Sun, Jialing Zhou, Lin Nong, ChangyuanGuo, Ping Lv, Quansheng Song, Can Zheng, Weiwei Liang, Shiyang Huang, Qingqing Li, Zhongtian Liu, Zhanming Song, Yuzi Li, Yu Zhang, Wei Kong, Hong You*, Jianzhong Xi*, and Ying Wang*. PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target. J Hepatol, 2020, 72(3):506-18.

6.      Yingbao Wang#, Dixin Chen#, Yan Zhang#, Pingzhang Wang, Can Zheng, Songyang Zhang, Bing Yu, Lu Zhang, Guizhen Zhao, Baihui Ma, Zeyu Cai, Nan Xie, Shiyang Huang, Ziyi Liu, Xiaoning Mo, Youfei Guan, Xian Wang, Yi Fu, Dalong Ma, Ying Wang*, Wei Kong*. A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2. Circulation, 2018, 138(1):48-63.

7.      Can Zheng#, Dixin Chen#, Yan Zhang, Yun Bai, Shiyang Huang, Danfeng Zheng, Weiwei Liang, Shaoping She, Xinjian Peng, Pingzhang Wang, Xiaoning Mo, Quansheng Song, Ping Lv, Jing Huang, Richard D. Ye*, Ying Wang*. FAM19A1 is a new ligand for GPR1 that modulates neural stem cell proliferation and differentiation. FASEB J, 2018, 32:5874-90.

8.      Li He, Yi Fu, Jingna Deng, Yi-Cong Shen, Yingbao Wang, Fang Yu, Nan Xie, Zhongjiang Chen, Tianpei Hong, Xin-Jian Peng, Qingqing Li, Jing-Yan Han*, Ying Wang*, Jianzhong Xi*, and Wei Kong*. Deficiency of FAM3D (Family with Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development. Arterioscler Thromb Vasc Biol, 2018, 38(7):1616-31.

9.      Xiaolei Pei#, Danfeng Zheng#, Shaoping She, Jing Ma, Changyuan Guo, Xiaoning Mo, Yingmei Zhang, Quansheng Song, Yu Zhang, Dalong Ma, and Ying Wang*. The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis. Sci Rep, 2017, 7(1): 5107.

10.   Xinjian Peng#, Enquan Xu#, Weiwei liang, Xiaolei Pei, Dixin Chen, Danfeng Zheng, Yang zhang, Can Zheng, Pingzhang Wang, Shaoping She, Yan Zhang, Jing Ma, Xiaoning Mo, Dalong Ma, Ying Wang*. Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors. J Cell Sci, 2016, 129, 1831-42.

11.   Xiaolei Pei#, Qianying Sun#, Yan Zhang#, Pingzhang Wang, XinjianPeng, Changyuan Guo, Enquan Xu, Yi Zheng, Xiaoning Mo, Jing Ma, Dixin Chen, Yang Zhang, Yingmei Zhang, Quansheng Song, Shuai Guo, Taiping Shi, Zhixin Zhang, Dalong Ma, Ying Wang*. PC3-secreted microprotein is a Novel Chemoattractant Protein and Functions as a High Affinity Ligand for CC Chemokine Receptor 2. J. Immunol, 2014, 192 (4):1878-86.

12.   Wenjuan Zhang, Michelle Mendoza, Xiaolei Pei, Sarah Mahoney, Didem Ilter, Yingmei Zhang, Dalong Ma, John Blenis*, Ying Wang*. Down-regulation of CMTM8 induces EMT-like changes and cell motility through c-MET-ERK signaling. J Biol Chem, 2012, 287, 11850-8.

13.   Linjie Tian#, Wen Li#, Jiaoli Wang#, Yan Zhang, Yi Zheng, Hui Qi, Xiaohuan Guo, Yingmei Zhang, Dalong Ma, Huahao Shen*, Ying Wang*. The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4- mediated chemotaxis in a mouse model of asthma. Allergy, 2011, 66: 287–97.

14.   Ying Wang, Dan Li, Hui Fan, Linjie Tian, Yingcheng Zhong, Yingmei Zhang, Lan Yuan, Caining Jin, Caihua Yin, Dalong Ma*. Cellular uptake of exogenous human PDCD5 protein. J Biol Chem, 2006, 281, 24803-17.

15.   王应，马大龙*。新细胞因子趋化素样因子(CKLF1)的发现与新药开发。中国药学杂志，2011, 46: 241-4.

(注：#并列第一，*通讯作者)