主要学习及工作经历 1984.9-1988.7 山东大学生物专业本科生 1994.7-1997.6 北京医科大学生药学专业博士生 1999.5-2007.10 密歇根州立大学生化及分子生物学系访问学者 博士后 1997.7-1999.5 北京医科大学生化及分子生物学系 讲师 2007.10- 北京大学医学部生物物理系 副教授

研究方向 蛋白质晶体结构

基金来源 教育部留学回国启动基金；北京市自然科学基金；国家自然科学基金

代表论文 1.Chang Z , Wang X, Wei R, Liu Z, Shan H, Fan G, Hu H (2010). Functional expression and purification of CYP 93C20, a membrane-associated cytochrome P450 from Medicago truncatula. Protein Expr Purif. 2010 Dec 4. [Epub ahead of print]. 2.Chang Z, Li L, Pan Z, Fu Z, Wang X (2008). Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase. Proc Natl Acad Sci USA 105 (37): 13883-13888. 3.Chang Z, Li L, Pan Z, Wang X (2008). Crystallization and preliminary x-ray analysis of allene oxide synthase, cytochrome P450 CYP74A from Parthenium argentatum. Acta Crystallogr F 64: 668-670. 4.Chang Z, Zhang L, Gage DA (2010). Analysis of tetrahydrofolate metabolites and folic acid in spinach and Arabidopsis thaliana by affinity chromatography and reversed-phase high performance liquid chromatography. 中国生物化学与分子生物学报 26 (9):862-870 5.Wang X, He X, Lin J, Shao H, Chang Z, Dixon RA (2006). Crystal structure of isoflavone reductase from alfalfa (Medicago sativa). J Mol Biol. 358(5):1341-1352. 6.Chang Z, Kuchar J and Hausinger RP (2004). Chemical cross-linking and mass spectrometric identification of sites of interaction of UreD, UreF, and urease. J Biol Chem. 279 (15): 15305-15313.