主要学习及工作经历

1998.07-2001.07：德国Freiburg大学，生物学，博士

1988.09-1991.07：首都儿科研究所，生化与免疫，硕士

1982.09-1988.07：北京医科大学，临床医学，本科

2011.08-今：        北京大学基础医学院，细胞生物学系，教授

2001.10-2011.07：北京大学基础医学院，细胞生物学系，副教授

1995.10-1998.06：首都儿科研究所，生化与免疫，副研究员

1993.10-1995.09：首都儿科研究所，生化与免疫，助理研究员

1991.09-1993.09：首都儿科研究所，生化与免疫，实习研究员

获奖情况

1. 2021年获北京大学杨芙清-王阳元院士教师优秀奖

2. 1996年获北京市茅以升青年科技奖

3. 1993年获北京市科学技术进步奖三等奖，人SRY基因的分离、克隆和应用的研究（陈虹,杜晓娟,黄秉仁）

4. 1993年获北京市科学技术进步奖二等奖，小儿心内膜心肌病的诊治研究（王惠玲, 孙国贤, 李巍, 于祖芬, 杜晓娟）

5. 1993年获国家科学技术进步奖二等奖，小儿病毒性心肌炎临床及实验研究（李家宜,孙国贤,郭行平,张霆,赵锦铭,马官福,崔晓岱, 韩玉龙,杜晓娟）

6. 1992年获卫生部科学技术进步奖二等奖，小儿病毒性心肌炎临床及实验研究（李家宜,孙国贤,郭行平,张霆,赵锦铭,马官福,崔晓岱, 韩玉龙,杜晓娟）

7. 1991年获北京市科学技术进步奖一等奖，小儿病毒性心肌炎临床及实验研究（李家宜,孙国贤,郭行平,张霆,赵锦铭,马官福,崔晓岱,韩玉龙,杜晓娟）

研究方向 肿瘤细胞生物学

基金来源 国家自然科学基金

代表论文

1.        Yuying Wang, Kunqi Su, Chang Wang, Tao Deng, Xiaofeng Liu, Shiqi Sun, Yang Jiang, Chunfeng Zhang, Baocai Xing* and Xiaojuan Du*, Chemotherapy-induced acetylation of ACLY by NAT10 promotes its nuclear accumulation and acetyl-CoA production to drive chemoresistance in hepatocellular carcinoma. Cell Death Dis. 2024 Jul 31;15(7):545. https://doi.org/10.1038/s41419-024-06951-9. PMID: 39085201.

2.        Kunqi Su, Zhuochen Zhao, Yuying Wang, Shiqi Sun, Xiaofeng Liu, Chunfeng Zhang, Yang Jiang*, Xiaojuan Du*，NAT10 resolves harmful nucleolar R-loops depending on its helicase domain and acetylation of DDX21. Cell Commun. Signal. 2024 Oct 11;22(1):490. https://doi.org/10.1186/s12964-024-01869-3. PMID: 39394182.

3.        Yang Jiang, Shiqi Sun, Xiaofeng Liu, Kunqi Su, Chunfeng Zhang, Peipei Zhang, Zhuochen Zhao, Ya Su, Chang Wang, Xiaojuan Du*，U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis. Cell Death Dis. 2024 May 17;15(5):342. https://doi.org/10.1038/s41419-024-06725-3. PMID: 38760378.

4.        Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*. PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition. J Exp. Clin. Cancer Res. 2022, 41 （1）:101. DOI : 10.1186/s13046-022-02302-8.

5.        Jiaojiao Zheng#, Yuqin Tan#, Xiaofeng Liu, Chunfeng Zhang, Kunqi Su, Yang Jiang, Jianyuan Luo, Li Li* and Xiaojuan Du*. NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation. Cell Death Differ. 2022, 29(4) :846-860. doi: 10.1038/s41418-021-00899-5.

6.        Xiaofeng Liu*, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du* and Baocai Xing*. Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway. J Exp. Clin. Cancer Res. 2021, 40(1):132.

7.        Jiaojiao Zheng, Chunfeng Zhang, Yuan Li, Yang Jiang, Baocai Xing*, and Xiaojuan Du*. p21-activated kinase 6 controls mitosis and hepatocellular carcinoma progression by regulating Eg5. BBA Mol. Cell Res., 2021;1868(2):118888. doi: 10.1016/j.bbamcr.2020.118888.

8.        Yuan Li#, Ling Wang#, Xiaofeng Liu, Chunfeng Zhang, Xiaojuan Du*, Baocai Xing*. NIR promotes progression of colorectal cancer through regulating RB. BBA Mol. Cell Res. 2021; 1868(1):118856. doi: 10.1016/j.bbamcr.2020.118856.

9.        Jingyi Zhang#, Pengwei Ren#, Da Xu#, Xiaofeng Liu, Zhenzhen Liu, Chunfeng Zhang, Yuan Lia, Lijun Wanga, Xiaojuan Du* and Baocai Xing*. Human UTP14a promotes colorectal cancer progression by forming a positive regulation loop with c-Myc. Cancer Letters. 2019, 440-441 :106-115.

Xiaofeng Liu, Shiying Cai, Chunfeng Zhang, Zhenzhen Liu, Jianyuan Luo, Baocai Xing* and Xiaojuan Du*. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucleic Acids Res., 2018 Oct 12;46(18):9601-9616.