主要学习及工作经历 1987,9-1993, 7： 白求恩医科大学英语医学专业 本科生 1993,9-1996, 6： 白求恩医科大学基础医学院免疫教研室 硕士研究生 1998,9-2001, 6： 吉林大学基础医学院免疫教研室 博士研究生  1996,7-1998,12： 白求恩医科大学基础医学院免疫教研室 助教 1999,2-2001, 2： 日本德岛大学基因组研究所 访问学者 2001,2-2003, 9： 吉林大学基础医学院免疫教研室 讲师  2003,9-2005, 7： 北京大学医学部免疫学系T细胞研究室 博士后  2005,8-2020,7： 北京大学医学部免疫学系T细胞研究室 副教授  2020,8-至今：北京大学医学部免疫学系研究员

主要学术任职 中国免疫学会会员 中国免疫学会自身免疫分会理事

获奖情况 获2008年度“北京大学医学部优秀青年学者”

研究方向 肿瘤免疫及免疫细胞治疗

基金来源 1、863 计划 2006AA02Z486“肿瘤疫苗候选抗原HCA-587的临床前研究” 320万 （2006-2009） 2、国家自然科学基金 30772500 “新型肿瘤特异抗原BJ-TSA-9在肺癌表达的临床意义及其功能研究” 29万 （2008-2010） 3、北京市自然科学基金 7071006 “肿瘤抗原的分析鉴定及可能的临床应用” 50万 （2007-2009） 4、国家自然科学基金 81071708 “癌/睾丸抗原HCA587对肿瘤细胞周期的调控作用及其机制” 31万 （2011-2013） 5、国家自然科学基金：81171974 “癌/睾丸抗原HCA587对转录因子NF-κB的调节作用研究 ” 60万 （2012-2015）6、北京市自然科学基金 7142087  “肿瘤/睾丸抗原HCA587在肿瘤转移中的作用及其机制研究”18万（2014,1-2016,12）7、国家自然科学基金 81472645“肿瘤抗原HCA587与STAT3的相互作用及其促进肿瘤转移的分子机制研究” 64万 （2015，1-2018，12）8、 国家自然科学基金 81671637   癌/睾丸抗原HCA587/MAGE-C2特异TCR基因修饰T细胞的建立及抗肿瘤作用研究 57万 （2017,1-2020,12）9、北京市自然科学基金 7192090  “肿瘤/睾丸抗原HCA587/MAGEC2对免疫抑制的肿瘤微环境形成的影响” 20万（2019,1-2021,12）

代表论文

1.   Yang W, Zhang W, Wang X, Tan L, Li H, Wu J, Wu Q, Sun W, Chen J*, Yin Y*. HCA587 protein vaccine induces specific antitumor immunity mediated by CD4+ T-cells expressing granzyme B in a mouse model of melanoma. 2021,21(6):738-746.  

2.   Wang Y, Song X, Zheng Y, Liu Z, Li Y, Qian X, Pang X, Zhang Y, Yin Y*. Cancer/testis antigen MAGEA3 interacts with STAT1 and remodels the tumor microenvironment. Int J Med Sci. 2018; 15：1702-1712.  

3.   Song X^#, Guo C^#, Zheng Y^#, Wang Y, Jin Z*, Yin Y*. Post -transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells. BMC Cancer. 2018;18(1): 971-980.  

4.   Zeng P^#, Wang Y^#, Zheng Y, Song X, Yin Y*. Cancer-testis antigen HCA587/MAGEC2 interacts with the general transcription coactivator TAF9 in cancer cells. Mol Med Rep. 2018; 17: 3226-3231.

5.   Hao J, Zhang Y, Yan X, Yan F, Sun Y, Zeng J, Waigel S, Yin Y, Yin Y, Fraig MM, Egilmez NK, Suttles J, Kong M, Liu S, Cleary MP, Sauter E, Li B*. Circulating adipose fatty acid binding protein is a new link underlying obesity-associated breast/mammary tumor development. Cell Metab. 2018; 6;28(5):689-705.

6.   Song X, Hao J, Wang J, Guo C, Wang Y, He Q, Tang H, Qing X, Li Y, Zhang Y, Yin Y*. The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling. Oncogene. 2017; 36(11): 1476–1486.

7.   Wang J^#, Song X^#, Guo C, Wang Y, Yin Y*. Establishment of MAGEC2-Knockout cells and functional investigation of MAGEC2 in tumor cells.  Cancer Sci. 2016; 107(12): 1888-1897.   

8.   Xiao Song^#, Wenjie Song^#, Ying Wang, Jingjing Wang, Yan Li, Xiaoping Qian, Xuewen Pang, Yu Zhang, Yanhui Yin*. MicroRNA-874 functions as a tumor suppressor by targeting cancer/testis antigen HCA587/MAGE-C2. J Cancer. 2016 ;7(6):656-663. 

9.  Sun X, Jin Z, Song X, Wang J, Li Y, Qian X, Zhang Y, Yin Y*. Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with  hepatocellular carcinoma. BMC Cancer. 2015; 15:961-969. 

10.  Hao J, Song X, Wang J, Guo C, Li Y, Li B, Zhang Y, Yin Y*. Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. Oncotarget. 2015; 6(19):42028-42039.  

11.  Li X, Peng J, Pang Y, Yu S, Yu X, Chen P, Wang W, Han H, Zhang J, Yin Y*, Zhang Y. Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma. Sci Rep. 2015; 5:14757-67. 

12.  Jiaqing Hao, Rui Shen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2014; 449(4): 386-391.

13.  Lijie Zhang, Juanjuan Chen, Xiao Song, Weigang Wen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer/Testis antigen HCA587-derived long peptide vaccine generates potent immunologic responses and antitumor effects in mouse model. Oncology Research. 2014;21(4):193-200.

14.Juanjuan Chen, Lijie Zhang, Weigang Wen, Jiaqing Hao, Pumei Zeng, Xiaoping Qian, Yu Zhang, Yanhui Yin*. Induction of HCA587-specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM. PLoS One. 2012;7（10）：e47219. 

15. Qing-Wen Xu, Wei Zhao, Yue Wang, Maureen A. Sartor1, Dong-Mei Han, Jixin Deng, Rakesh Ponnala, Jiang-Ying Yang, Qing-Yun Zhang, Guo-Qing Liao, Yi-Mei Qu, Lu Li, Fang-Fang Liu, Hong-Mei Zhao, Yan-Hui Yin, Wei-Feng Chen, Yu Zhang, and Xiao-Song Wang. An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer. Cancer Res. 2012; 72(24):6351-61. 

16. Wen W, Zhang L, Peng J, Chen J, Hao J, Li X, Qian X, Zeng P, Zhang Y, Yin Y* Identification of promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the cancer-testis antigen HCA587. Cancer Sci. 2011;102(8): 1455-1461.

17. Yan-Li Pang, Hua-Gang Zhang, Ji-Run Peng, Xue-Wen Pang, Shu Yu, Qiao Xing, Xin Yu, Lei Gong, Yan-hui Yin, Yu Zhang, Wei-Feng Chen. The immunosuppressive tumor microenviroment in hepatocellular carcinoma. Cancer Immunol Immunother. 2009;58：877-886 5. 

18. Lei Liu, Guo-qing Liao, Pei He, Hong Zhu, Peng-hui Liu, Yi-mei Qu, Xiao-ming Song, Qing-wen Xu, Qian Gao, Yu Zhang, Wei-feng Chen* and Yan-hui Yin*. Detection of circulating cancer cells in lung cancer patients with a panel of marker genes. Biochem Biophys Res Commun. 2008;372 (4): 756-760. 

19. Qiao Xing, Xue-Wen Pang, Ji-Run Peng, Yan-Hui Yin, Yan Li, Xin Yu, Shu-Pei Zhou, Yu Zhang, and Wei-Feng Chen*. Identification of new cytotoxic T-lymphocyte epitopes from cancer testis antigen HCA587. Biochem Biophys Res Commun. 2008; 372 (2):331-335. 

20. Dong XY, Peng JR, Ye YJ, Chen HS, Zhang LJ, Pang XW, Li Y, Zhang Y, Wang S, Fant ME, Yin YH*, Chen WF*. Plac1 is a tumor-specific antigen capable of eliciting spontaneous antibody responses in human cancer patients. Int J Cancer. 2008; 122 (9):2038-43. 

21. Liu FF, Dong XY, Pang XW, Xing Q, Wang HC, Zhang HG, Li Y, Yin YH, Fant M, Ye YJ, Shen DH, Zhang Y, Wang S*, Chen WF*. The specific immune response to tumor antigen CP1 and its correlation with improved survival in colon cancer patients. Gastroenterology. 2008;134 (4):998-1006. 

22. Y-H Yin, Y-Y Li, H Qiao, H-C Wang, X-A Yang, H-G Zhang, X-W Pang, Y Zhang and W-F Chen*. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. British Journal of Cancer. 2005;93:458-463. 

23. Y-Y Shi#, H-C Wang#, Y-H Yin#, W-S Sun, Y Li, C-Q Zhang, Y Wang, S Wang and W-F Chen*. Identification and analysis of tumour-associated antigens in hepatocellular carcinoma. British Journal of Cancer. 2005; 92:929-934.