黄薇心血管 ,,硕导
电话:82801589
E-mail:huangwei@bjmu.edu.cn
办公地址:中心实验楼817
主要学习及工作经历
1986-1991:华中科技大学同济医学院临床医学学士学位
1991-1993:华中科技大学同济医学院附属协和医院内科住院医师
1995-1996:巴黎七大生物医学硕士学位 (Master)
1996-2001:巴黎七大生物医学博士学位(PhD)
2001-2002:法国国家健康医学研究学院U367 (心血管生理病理研究所) 博士后
2003-至今: 北京大学医学部心血管研究所任副教授
2018-至今: 北京大学医学部心血管研究所副所长
主要学术任职
中国生理学会副秘书长
中国病生理学会心血管专委会委员
北京生理学会常务理事、北京生理学会心血管病专委会副主任委员
《生理通讯》副主编
《中国医学前沿杂志》及《基础医学与临床》编委
研究方向
脂代谢紊乱在糖尿病血管病变中的作用、机制及治疗研究。包括Seipin, ApoCIII,GPIHBP1及LPL等甘油三酯代谢相关基因在血管、肾及心脏中的作用及机制研究。
基金来源
获5项国家自然科学基金面上项目资助,973骨干两项,863参与一项。
在研国家自然科学基金面上项目1项。
代表论文
1. Huang W#., Alhenc Gelas F.and Osborne-Pellegrin M. J. Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat. Circulation Research.1998, 82: 879-90. (IF: 9.8)
2. Huang W#., Gallois Y., Bouby N., Bruneval P., Heudes D., Belair M.F., Krege J.H., Meneton P., Marre M., Smithies O., and Alhenc-Gelas F. Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse . Proc Natl Acad Sci USA. 2001, 98(23):13330-4. (IF: 9.6)
3. Wang H#, Huang X#, Xu P, Liu X, Zhou Z, Wang F, Li J, Wang Y, Xian X, Liu G, Huang W*. Apolipoprotein C3 aggravates diabetic nephropathy in type 1 diabetes by activating the renal TLR2/NF-κB pathway. Metabolism. 2021 Jun; 119:154740. doi:10.1016 / j. metabol. 2021.154740. Online ahead of print. (IF 8.9)
4. Wu XY#, Liu XJ#, Wang H, Zhou ZH, Yang CZ, Li ZJ, Zhang YY, Shi XL, Zhang L, Wang YH, Xian XD, Liu G, Huang W*. Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice. Frontiers in Cardiovascular Medicine. 2021Mar 11;8: 644128. doi: 10.3389 / fcvm.2021.644128 (IF 6.05)
5. Wang F#, Wang H, Liu X, Yu H, Huang X, Huang W*, Wang G*.Neuregulin-1 alleviate oxidative stress and mitigate inflammation by suppressing NOX4 and NLRP3/caspase-1 in myocardial ischaemia-reperfusion injury. J Cell Mol Med. 2021Feb;25(3):1783-1795. (IF5.31)
6. Liu X#; Li J#; Liao J; Wang H; Huang X; Dong Z; Shen Q; Zhang L; Wang Y; Kong W; Liu G; Huang W*. Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr-/- mice. Atherosclerosis. 2019, 282: 100-109. (IF: 4.3)
7. Wang H#; Xu PF#; Li JY; Liu XJ; Wu XY; Xu F; Xie BC, ; Huang XM,; Zhou ZH; Kayoumu A; Liu G; Huang W*. Adipose tissue transplantation ameliorates lipodystrophy-associated metabolic disorders in seipin-deficient mice. Am J Physiol Endocrinol Metab. 2019, 316(1): E54--E62. (IF: 4.1)
8. Liu XJ#; Wu XY; Wang H; Wang SX; Kong W; Zhang L; Liu G; Huang W*. Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue–kidney crosstalk. FASEB J. 2018, 32(10): 5550-5562.(IF: 5.59)
9. Wang FH#; Wang H; Liu XJ; Yu H; Zuo B; Song Z; Wang N; Huang W*; Wang GS*. Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway. Molecular Medicine. 2018, 24(1): 39-51. (IF: 3.4)
10. Liao J#; Guo X; Wang M; Dong C; Gao M; Wang H; Kayoumu A; Shen Q; Wang Y; Wang F; Huang W*; Liu G. Scavenger Receptor Class B Type 1 Deletion Led to Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor Knockout Mice on Modified Western-type. J Atheroscler Thromb. 2017, 24(2): 133-146. ( IF: 3.0)