主要学习及工作经历 1988.8----1993.7 北京医科大学临床医学专业本科 1999.8----2000.3 日本大阪大学第一内科研究生 2000.4----2004.7 日本大阪大学第一内科博士 1993.7----1999.8 北京协和医院心内科医师 2004.12----现在 北京大学心血管研究所副教授

研究方向 semaphorin在心血管发育和脂肪代谢中的作用

基金来源 973子课题 semaphorin在心血管发育中的作用 88万

代表论文 1. Liu,w, Li,jj, Liu,m,Wang N, Zhang H.Sema3G is a target gene of PPAR- and play a role in Endothelial cell migration. JBC, 责任作者正在投稿中。 2. Li,Y, Zhao B, Wang N, Zhang H. Rosiglitazone attenuates angiotensin II-induced versican expression and extracellular matrix production in rat arteries. Cardiovascular Research, 责任作者正在投稿中 3. Zhang H, Li Y, Fan Y, Wu J, Zhao B, Guan Y, Chien S, Wang N. Klotho is a target gene of PPAR-gamma. Kidney Intl 2008; 74:732-9. 本文有重大意义，在同期杂志中有评述。见同期杂志702页 4. Fan Y, Wang Y, Zhang H, Qin X, Zhu Y, Guan Y, Wang X, Staels B, Chien S, Wang N. Suppression of Pro-inflammatory Adhesion Molecules by PPAR- in Human Vascular Endothelial Cells. Arterioscler Thromb Vasc Biol. 2008; 28:315-2. 5. Toyofuku T*, Zhang H*, Kumanogoh A, Takegahara N, Suto F, Kamei J, Kazuhiro A, Yabuki M, Hori M, Fujisawa H, Kikutani H. Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with Off-Track and vascular endothelial growth receptor type2. Gene & Development, 2004，18:435-447. （*共同第一作者） 6. Toyofuku T, Yoshida J, Sugimoto T, Zhang H, Kumanogoh A, Hori M, Kikutani H. FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat Neurosci. 2005，8:1712-9. 7. Toyofuku T, Zhang H, Kumanogoh A, Takegahara N, Yabuki M, Harada K, Hori M, Kikutani H. Guidance of myocardial patterning in cardiac development by bi-directional Sema6D signals. Nature Cell Biol, 2004，6:1204-1211. 8. Zhang H, Toyofuku T, Kamei J, Hori M. GATA-4 regulates cardiac morphogenesis through transactivation of the N-cadherin gene. Biochemical and Biophysical Research Communications 2003, 312:1033-1038. 9. Toyofuku T, Akamatsu Y, Zhang H, Kuzuya T, Tada M, Hori M. c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes. J Biol Chem. 2001, 276:1780-1788. 10. Toyofuku T, Zhang H, Kuzuya T, Tada M, Hori M. Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J Cell Biol. 2000, 150:225-241.