主要学习及工作经历 1994.9－1999.7西安医科大学临床医学专业，获医学学士学位； 1999.9－2002.9西安交通大学医学院生理系，获生理学硕士学位； 2005.9-2009.7 北京大学医学部生理系，获生理学博士学位； 2002.8至2018.8 北京大学医学部生理学与病理生理学系 讲师 2018.8至今 北京大学医学部生理学与病理生理学系 副教授

主要学术任职 中国生理学会会员，中国病理生理学会会员，国际心脏研究会中国分会会员

研究方向 心血管生理学，目前主要研究方向为血管力学生物力学

基金来源 作为项目负责人承担国家青年科学基金项目“可溶性表氧化物水解酶在血管紧张素Ⅱ所致心肌肥大中的作用及机制”（已结题） 作为项目负责人承担国家自然科学基金面上项目“可溶性表氧化物水解酶在动脉粥样硬化中的作用及机制” 2015/01-2018/12（已结题）;作为项目负责人承担北京市自然科学基金面上项目，"血管移植术后内膜增生的力学生物学机制研究-线粒体融合蛋白2的作用"，2021/1-2023/12（已结题）。

代表论文

1. Tang Y, Jia Y, Fan L, Liu H, Zhou Y, Wang M, Liu Y, Zhu J, Pang W*, Zhou J*. MFN2 Prevents Neointimal Hyperplasia in Vein Grafts via Destabilizing PFK1. Circ Res. 2022;130(11): e26-e43. 
2. Jiang Z, Zhu J, Zhao C, Tang Y, Liu H, Zhao J, Zhang J, Liu Y, Yao W, Han L, Pang W*, Zhou J*. Shear stress regulates the SNAP23-mediated endothelial secretion of VWF through the GPR68/PKA/vimentin mechanotransduction pathway. Biochem Biophys Res Commun. 2022; 607:166-173. 

3. Pang W, Li N, Ai D, Niu XL, Guan YF, Zhu Y. Activation of Peroxisome Proliferator- Activated Receptor γ Downregulates Soluble Epoxide Hydrolase in Cardiomyocytes. Clin Exp Pharmacol Physiol. 2011 Feb 3. 

4. Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy.Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):564-9. 

5. Wang Q*, Pang W*, Cui Z, Shi J, Liu Y, Liu B, Zhou Y, Guan Y, Hammock BD, Wang Y, Zhu Y*. Upregulation of Soluble Epoxide Hydrolase in Proximal Tubular Cells Mediated Proteinuria-induced Renal Damage. Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F168-76. 

6. Liu J, Wang J, Liu Y, Xie SA, Zhang J, Zhao C, Zhou Y, Pang W, Yao W, Peng Q, Wang X, Zhou J: Liquid-Liquid Phase Separation of DDR1 Counteracts the Hippo Pathway to Orchestrate Arterial Stiffening. Circ Res. 2023;132 (1), 87-105.
7. Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J. Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation. Adv Sci (Weinh). 2022;e2203995. 
8. Wang J, Xie SA, Li N, Zhang T, Yao W, Zhao H, Pang W, Han L, Liu J, Zhou J. Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis. Bioact Mater. 2022;17:406-424.
9.  Zhao CR, Yang FF, Cui Q, Wang D, Zhou Y, Li YS, Zhang YP, Tang RZ, Yao WJ, Wang X, Pang W, Zhao JN, Jiang ZT, Zhu JJ, Chien S, Zhou J. Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation. Proc Natl Acad Sci U S A. 2021;118(48):e2115158118.
10. Liu YF, Zhu JJ, Yu Tian X, Liu H, Zhang T, Zhang YP, Xie SA, Zheng M, Kong W, Yao WJ, Pang W, Zhao CR, Tang YJ, Zhou J. Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis. 2020;11(1):35.
11. Tang RZ, Zhu JJ, Yang FF, Zhang YP, Xie SA, Liu YF, Yao WJ, Pang W, Han LL, Kong W, Wang YX, Zhang T, Zhou J. DNA methyltransferase 1 and Krüppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis. J Mol Cell Cardiol. 2019; 128:11-24.
12. Xie SA, Zhang T, Wang J, Zhao F, Zhang YP, Yao WJ, Hur SS, Yeh YT, Pang W, Zheng LS, Fan YB, Kong W, Wang X, Chiu JJ, Zhou J. Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1. Biomaterials. 2018;155:203-216.
13. Zhu JJ, Liu YF, Zhang YP, Zhao CR, Yao WJ, Li YS, Wang KC, Huang TS, Pang W, Wang XF, Wang X, Chien S, Zhou J. VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia. Proc Natl Acad Sci U S A. 2017;114(31):8271-8276.

14. Dang H, Liu Y, Pang W, Wang N, Shyy JY, Zhu Y. Suppression of 2,3-oxidosqualene cyclase by high-fat diet contributes to liver X receptor-alpha -mediated improvement of hepatic lipid profile. J Biol Chem. 2009 Jan 1.  15. Xia Q, Pang W, Pan H, Zheng Y, Kang JS, Zhu SG. Effects of ghrelin on the proliferation and secretion of splenic T lymphocytes in mice. Regul Pept. 2004 Nov 15;122(3):173-8. 7. Jiang ML, Han TZ, Pang W, Li L. Gender- and age-specific impairment of rat performance in the Morris water maze following prenatal exposure to an MRI magnetic field. Brain Res. 2004 Jan 2;995(1):140-4. 

16. Dan Li, Yajin Liu, Xu Zhang, Huizhen Lv,Wei Pang, Xiaoli Sun, Li-Ming Gan, Bruce D.Hammock, Ding Ai, Yi Zhu. Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice,Journal of Molecular and Cellular Cardiology, 2016 Sep;98:128-37.