李肖霞生理 ,副教授
电话:82805613
E-mail:lixiaoxia@bjmu.edu.cn
办公地址:北京大学医学部生理楼318
主要学习及工作经历
1995. 9—2000. 7 北京大学医学部 临床医学 本科
2000. 9—2005. 7 北京大学医学部 干细胞生物学 硕博连读
2010. 5—2011.12 在美国国立卫生研究所(NIH)以博士后访问学者身份进修培训。 2005年8月至今,在北医生理系担任讲师,主要探讨影响血管内皮祖细胞增殖、分化的分子机制及成体干细胞的多向分化潜能。
主要学术任职
中国生理学会会员
研究方向
影响血管内皮祖细胞增殖、分化的分子机制及成体干细胞的多向分化潜能。
基金来源
蛋白激酶AMPK与AKT 在内皮祖细胞增殖分化的作用及机制研究. 国家自然基金青年基金项目 (30600209), RMB 230,000,2006-2009。
转录因子KLF2与KLF4在内皮祖细胞增殖分化中的调节作用及机制研究。国家自然基金面上项目 (81070113), RMB 330,000,2011-2013。
代表论文
1. Li X*, Song Y, Han Y, Wang D, Zhu Y. Liver X receptor agonist alleviated high glucose-induced endothelial progenitor cell dysfunction via inhibition of reactive oxygen species and activation of AMP-activated protein kinase Microcirculation. 2012 Aug;19 (6):547-53. (* corresponding author ) (IF: 2.574)
2. Li X*, Song Y, Wang D, Fu C, Zhu Z, Han Y, Li C, Wang N, Zhu Y. LIF maintains progenitor phenotype of endothelial progenitor cells via Krüppel-like factor 4. Microvasc Res. 2012 Jul 23. [Epub ahead of print] (* corresponding author ) (IF: 2.828)
3. Alnaeeli M, Wang L, Piknova B, Rogers H, Li X, Noguchi CT. Erythropoietin in brain development and beyond. Anat Res Int. 2012;2012:953264. Epub 2012 Feb 26. (review article)
4. Zhu Z, Fu C, Li X, Song Y, Li C, Zou M, Guan Y, Zhu Y. Prostaglandin E2 promotes endothelial differentiation from bone marrow-derived cells through AMPK activation. PLoS One. 2011;6(8):e23554. Epub 2011 Aug 18. (IF: 4.22)
5. Deng XL, Li XX (co-first author), Liu XY, Sun L, Liu R. Comparative study on circulating endothelial progenitor cells in systemic lupus erythematosus patients at active stage.. Rheumatology International (Clinical and Experimental Investigations) 2009 Oct 22. [Epub ahead of print]. (IF: 1.327)
6. Li X, Han Y, Pang W, Li C, Xie X, Shyy JY, Zhu Y.AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1789-95. Epub 2008 Jul 3. (IF: 7.2)
7. Li Y, Chi XC, Li XX (co-first author), Xu JC Multipotency of human neural stem cells from fetal striatum Neuroreport. 2008 Nov 19;19(17):1679-83. (IF: 2.137)
8. Xiaoxia Li, Li Shen*, Jinchong Xu, Yun Bai, et al. Isolation and characterization of neural stem cells from human fetal striatum. Biochemical and Biophysical Research Communications 326 (2005) 425–434. (IF: 2.855)
9. Xuan Wang, Xiaoxia Li, Kun Wang, Huifang Zhou, et al. Forskolin cooperating with growth factor on generation of dopaminergic neurons from human fetal mesencephalic neural progenitor cells. Neurosci Lett. 2004 May 20; 362(2):117-21. (IF: 2.092)
10. Guanghui Xu, Xiaoxia Li, Yun Bai, Jinzhu Bai, Li Shen, Lingsong Li. Improving recovery of spinal cord-injured rats by telomerase-driven human neural progenitor cells, Restor Neurol Neurosci. 2004; 22(6):469-76. (IF: 2.862)