主要学习及工作经历 2004.8-2008.7 清华大学生物科学与技术系本科生 2008.8-2013.5 美国北卡罗来纳大学教堂山分校细胞和发育生物学系博士生 2013.5-2015.2 霍华德休斯研究所/美国北卡罗来纳大学教堂山分校博士后 2015.2至今 北京大学系统生物医学研究所特聘研究员

研究方向 1. 细胞迁移和肿瘤转移 2. 细胞骨架和细胞器

基金来源 北大百人100万元 2014-2017

代表论文 2015年： Rotty JD#, Wu C#, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE*. Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways. Dev Cell. 2015 Andrade DM, Clausen MP, Keller J, Mueller V, Wu C, Bear JE, Hell SW, Lagerholm BC, Eggeling C. Cortical actin networks induce spatio-temporal confinement of phospholipids in the plasma membrane - a minimally invasive investigation by STED-FCS. Sci Rep. 2015 2013年： Wu C, Haynes EM, Asokan SB, Simon JM, Sharpless NE, Baldwin AS, Davis IJ, Johnson GL, Bear JE*. Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling. J Cell Biol. 2013 New insights into the regulation and cellular functions of the ARP2/3 complex. Rotty JD, Wu C, Bear JE*. Nat Rev Mol Cell Biol. 2013 2012年： Wu C#, Asokan SB#, Berginski ME, Haynes EM, Sharpless NE, Griffith JD, Gomez SM, Bear JE*. Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell. 2012 2011年： Zhang W, Fu S, Liu X, Zhao X, Zhang W, Peng W, Wu C, Li Y, Li X, Bartlam M, Zeng ZH, Zhan Q, Rao Z*. Crystal structure of human Gadd45γ reveals an active dimer. Protein Cell. 2011