主要学习及工作经历 1955.9-1961.7 莫斯科第一医学院本科生 1961.9-1962.12 中山医学院助教 1963.1-至今 北京大学医学部助教(1963.1-1979.12)→讲师（1980.1-1985.8）→副教授(1985.9-1988.8)→教授(1988.9-至今)

主要学术任职 世界卫生组织西太区消灭脊髓灰质炎证实委员会委员、世界卫生组织西太区控制乙型肝炎专家工作组成员、世界肝炎联盟公共卫生学专家、国家药典委员会委员、中华预防医学会副会长、中华医学会理事、中华医学会肝病学分会名誉主任委员，以及 <<中国病毒病杂志>>等十余种期刊的总编、名誉总编、常务编委、编委或顾问。

获奖情况 先后获美国专利一项、国家科技进步二等奖二项、国家新药证书三项、卫生部科技进步一、二、三等奖、教育部科技进步二等奖(基础类)、教育部科技进步二等奖、中国人民解放军总后勤部科技进步二等奖、中华医学科技进步一等奖、浙江省科技进步一等奖、北京市科技进步一等奖等各一项，中华医学科技进步二等奖二项，北京市科技进步二等奖二项和三等奖四项等。

研究方向 病毒性肝炎

基金来源 国家十一五重大专项

代表论文 1. Liu BM, Li T, Xu J, Li XG, Dong JP, Yan P, Yang JX, Yan L, Gao ZY, Li WP, Sun XW, Wang YH, Jiao XJ, Hou CS, Zhuang H. Characterization of antiviral resistance-related mutations in hepatitis B virus reverse transcriptase sequences in treatment na?ve Chinese patients. Antiviral Research 2010; 85:512-519. 2. Lu FM, Zhuang H. Epidemiology and prevention of hepatitis B virus infection in China. J Vir Hepat 2010; 17 (Suppl. 1):4-9. 3. Yang JX, Liu BM, Li XG, Yan CH, Xu J, Sun XW, Wang YH, XJ, Ling Yan1, Dong JP, Hou CS, Abuduheilili XNY, Li T and Zhuang H. Profile of antiviral resistance mutations within HBV reverse transcriptase in distinct evolutionary pathways refractory to nucleos(t)ide analogue treatment among Chinese patients with chronic HBV infection. Antiviral Therapy 2010; 15(8):1171-1181. 4. Fu HW, Li LJ, Zhu YH, Wang L, Geng JB, Chang YB, Xue C, Du G, Li YN, Zhuang H. Hepatitis E virus infection among animals and humans in Xinjiang, china: Possibility of swine to human transmission of sporadic hepatitis e in an endemic area. Amer J Trop Med Hyg 2010; 82(5): 961-966. 5. Li LJ, Zhu YH, Ji YL, Liang JR, Fu HW, Wang L, Wei XF, Tang RL, Zhuang H. Ful1-genome nucleotide sequence and analysis of a Chinese swine isolate of genotype 4 identified in Guangxi Zhuang Autonomous Region: evidence of zoonotic risk from swine to human in South China. Liver International 2009; 29(8):1230-1240. 6. Li YJ, Xie Q, Lu FM, Zhao JM, Mao PY, Li Z, Liu S and Zhuang H. Association between epidermal growth factor 61A/Gpolymorphismand hepatocellular carcinoma susceptibility in Chinese patients. Liver International 2010; 30(1):112-118. 7. Ji YL, Zhu YH, Liang JR, Wei XF, Yang X, Wang L, Li LJ, Chang YB, Tang RL, Zhuang H. Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta). J Gastroenterol 2008; 43(7):565-570 8. Du H, Li T, Zhang HY, He ZP, Dong QM, Duan XZ, Zhuang H. correlation of hepatitis B virus (HBV) genotypes and mutations in basal core promoter / precore with clinical features of chronic HBV infection. Liver International 2007; 27(2):240-246. 9. Gao ZY，Li T, ang J, Du JM, Li YJ, Li J, Lu FM, Zhuang H. Mutations in preS genes of genotype C in hepatitis B virus patients with chronic hepatitis B and hepatocellular carcinoma. J Gastroenterol 2007; 42(9):761-768. 10. Ren FR, Lv QS, Zhuang H, Li JJ, Gong XY, Gao GJ, Liu CL, Wang JX, Yao FZ, Zheng YR, Zhu FM, Tiemuer MHL, Bai XH, Shan H.. Significance of the signal-to-cutoff rations of anti-hepatitis C virus enzyme immunoassays in screening of Chinese blood donors. Transfusion 2005; 45:1816-1822.