主要学习及工作经历

2011-2014 北京大学 博士

2007-2010 沈阳药科大学 硕士

2000-2004 华中科技大学 学士

2024- 北京大学第一医院 双聘教授

2023- 北京大学口腔医院 双聘教授

2023- 北京大学基础医学院 研究员，长聘副教授

2017-2023 北京大学基础医学院，研究员，助理教授  

2014-2016 北京大学基础医学院 博士后

2004-2007 国家药品审评中心 

主要学术任职

Chem, Advanced Materials, Nature Communications, Advanced Functional Materials, Advanced Science, Nano Letters，Acta Pharmaceutica Sinica B等杂志审稿人

获奖情况 北京市杰青

研究方向 生物材料，生物制造

基金来源

1) 国家自然科学基金委员会，重大项目课题，22595464，调控“未病”的有效物质体内传递规律和临床作用强化机制，2026-01至2030-12，350万，在研，主持

2) 北京市自然科学基金委员会，重点研究专题，24L20637，靶向重激活HIF-1α降解通路抑制儿童神经母细胞瘤的分子机制及类病毒递送策略，2024-10至2027-09，100万元，在研，主持

3) 国家自然科学基金委员会，面上项目，22378004，靶向3CLpro蛋白降解纳米载体的设计优化与抗病毒效应，2024-01至2027-12，50万元，在研，主持

4) 横向课题，北京百替生物技术有限公司，CAR-M细胞疗法载体制备技术，2023-09-01至2028-12-31，100万元，在研，主持

5) 北京市自然科学基金委员会，杰出青年科学基金，基于PROTAC设计的靶向STING蛋白降解聚合物用于系统性红斑狼疮治疗的研究，JQ21038，2021-12至2024-12，100万，结题，主持

6) 教育部，中国高校产学研创新基金，无菌护创液体敷料促进癌性伤口愈合的临床研究及升级创新，2021JH051，2022-05至2023-05，20万，结题，主持
7) 北京市自然科学基金委员会，海淀原始创新联合基金-前沿项目，pH敏感型ALK靶蛋白降解递送系统用于抗儿童神经母细胞瘤耐药的研究，2020-12至2023-12，L202049，28万，结题优秀，主持
8) 国家自然科学基金委员会，区域创新发展联合基金-重点支持项目，基于靶蛋白降解嵌合体的高靶向抗肿瘤递送系统的设计优化与作用机制，U20A20412，2021-01至2024-12，260万元，参与（承担经费87万元）
9) 国家十三五“重大新药创制”科技重大专项项目（任务级），2019年度“儿童用药品种及关键技术研发”新增品种：北京大学-盐酸小檗碱，2018ZX09721003-002-013，2019-01至2021-06，72万，已结题，主持
10) 北京大学，2022 年度北大医学青年科技创新发展平台青年培育基金A，靶向横纹肌肉瘤 HIF-1α蛋白降解剂的设计优化及作用机制，BMU2022PY009，2022-1至2022-12，12万，已结题，主持
11) 北京大学，人才专项基金，BMU2022RCZX016，2022-1至2023-12，30万，已结题，主持
12) 国家工程实验室-口腔数字化医疗技术和材料，开放课题，载药磷酸钙脂质体-3D 打印复合支架用于年轻恒牙牙髓修复的研究，PKUSS20200202，2020-11至2022-10，5万，已结题，主持
13) 兵团国际科技合作计划，肿瘤特异性显像纳米探针用于荧光引导手术治疗的研究，2019BC006，2019-01至2021-12，80万，已结题，参与
14) 北京大学，北京大学医学部引进人才计划与启动项目，基于药物创新制剂的系统药学学科平台建设，BMU2017YJ001，150万，2017-06至2019-12，已结题，主持

代表论文

1） Li, Yi^#; Liao Jun^#; Li, Songwei^#; Xiao, Zhicheng; Gao, Zhonghao; Fan, Jinhui; Wang, Yun; Wang, Tingfang; Zhang, Qiang; Zhang, Chuan*; Lin, Zhiqiang*; Guo, Yuewei*. Marine Materials: New Hope for Biomedical Applications. Cell Biomaterials. Pre-accept

2）  Wu, Yijuan#; Liao, Jun#; Pu, Yicheng; Gong, Lidong; Liu, Xingyu; Wu, Yuwei; Zhang, Qiang; Gu, Fen*; Wang, Yuanyuan*; Lin, Zhiqiang*. Mechanistic insights and therapeutic applications of metal-based nanomaterials in oral infectious diseases: Current advances and future perspectives. Biomaterials. 2026; 324:123528. doi:10.1016/j.biomaterials.2025.123528.

3）  Ruan, Zhijin; Yue, Lizhou*; Liu, Bin; Kim, Eunji; Chen, Xiaoqiang; Li, Jun; Jang, Hoyeon; Lin, Zhiqiang*; Li, Mingle*;Peng, Xiaojun; Kim, Jong Seung*. Visualizing pulmonary pathologies using smart molecular fluorescent probes. Coordination Chemistry Reviews. 2025, 545: 217025. doi: 10.1016/j.ccr.2025.217025.

4）  Luo, Yujie^#; Zhu, Chuanda^#; Guo, Xuefei^#; Xie, Yunfei^#; Lu, Dan; Ma, Guanghui*; Xia, Yufei*; Lin, Zhiqiang*; You, Fuping*. NanoCa with atypical crystal structure promotes BMDC maturation by activating IFNBand synergies with anti-PD-1 immunotherapy. Advanced Materials. 2025, 37(42): 2419870. doi: 10.1002/adma.202419870.

5）  Yang, Yuanyuan, Hu, Jiapan*, Mei, Fan, Gan, Yangyang, Ma, Qiang, Zhu, Chuanda, Gong, Lidong*, Lin, Zhiqiang*. Metal Ion Nanodepots Orchestrate Neuronal Axon and Dendrite Growth via the Actin-PFN1 Pathway. ACS Applied Materials & Interfaces, 2025;17(28):41067-41079. doi:10.1021/acsami.5c07533.

6）  Yang, Yuanyuan^#; Zhu, Chuanda^#; Wang, Xiaojun^#; Gong, Lidong; Ma, Qiang; Luo, Yujie; Wang, Hongjun; Lu, Dan; Li, Ridong; Zhang, Qiang; Lin, Zhiqiang*. A viral infection-biomimetic strategy for antibody-guided targeted protein degradation. Acta Biomaterialia. 2025; 205:659-671. doi:10.1016/j.actbio.2025.08.030.

7）  Gong, Lidong; Liang, Zichao; Ning, Xianling; He, Jianan; Huang, Junjie; Li, Runtao; Yin, Yuxin*; Li, Ridong*; Lin, Zhiqiang*. Molecular hybridization-driven FAK inhibitors: N-2,4-diarylaminopyrimidine-3-sulfamoyl-benzamide derivatives with improved antitumor potency. European Journal of Medicinal Chemistry, 2025;296:117885. doi:10.1016/j.ejmech.2025.117885.

8）  Pu, Yicheng; Zhu, Chuanda; Liao, Jun; Gong, Lidong; Wu, Yijuan; Liu, Shunquan; Wang, Hongjun; Zhang, Qiang; Lin, Zhiqiang*. Antiviral Nanomedicine: Mechanisms and Advanced Therapies. Bioactive Materials, 2025, 52:92-122. doi:10.1016/j.bioactmat.2025.05.030.

9）  Zhang, Shiming^#; Wang, Tianyu^#; Gao, Tianzi; Liao, Jun; Wang Yang; Xu, Meng; Lu, Changyu, Liang Jianfeng; Xu zhengren; Sun, Jianfei; Xie, Qian*; Lin, Zhiqiang*; Han, Hongbin*. Imaging probes for the detection of brain microenvironment. Colloids and Surfaces B: Biointerfaces,2025; 252:114677. doi:10.1016/j.colsurfb.2025.114677.

10）Zhang, Shiming^#; Shang, Kun^#; Gong, Lidong; Xie, Qian; Sun, Jianfei; Xu, Meng; Wei, Xunbin; Xie, Zhaoheng; Liu, Xinyu; Tang, Hao; Xu, Zhengren; Wang, Wei; Xiao, Haihua*, Lin, Zhiqiang*; Han, Hongbin*. Smart Organic-inorganic Copolymer Nanoparticles Distinguish between Microglia and Cancer Cells for Synergetic Immunotherapy in Glioma. Advanced Science, 2025;12(25):e2500882. doi:10.1002/advs.202500882.

11）Zhu, Chuanda; Ma, Qiang*; Gong, Lidong*; Liang, Ling*; Lin, Zhiqiang*. Recent Advances and Challenges in Metal-Based Antimicrobial Materials: A Review of Strategies to Combat Antibiotic Resistance. Journal of Nanobiotechnology, 2025, 23 (1):193. doi:10.1186/s12951-025-03249-6.

12）Liao, Jun; He, Wenxiu; Li, Lisha; Wang, Jingya; Gong, Lidong; Zhang, Qiang, Lin, Zhiqiang*. Mitochondria in Brain Diseases: Bridging Structural-Mechanistic Insights to Precision Targeted Therapies. Cell Biomaterials, 2025 (1):100016. doi: 10.1016/j.celbio.2025.100016

13）Liao, Jun; He, Wenxiu; Zhang, Shiming; Wang, Jingya; Cheng, Hansen; Gong, Lidong; Li, Yanglonghao; Sun, Yuhua; Lu, Dan; Zhang, Chuan; Lu, Ying; Zhang, Qiang; Lin, Zhiqiang*. Magnetic Field Driven Ceria Nanosystems for Mitochondria Targeted Therapy of Ischemic Stroke. Advanced Functional Materials, 2025, 35, 2423291. doi: 10.1002/adfm.202423291.

14）Zhang, Lixin^#; Ning, Xianling^#; Cui, Jingyi; Zhao, Yanqiang; Xie, Fei; Zhu, Ningxin; Wang, Dan; Qin, Man; Lin, Zhiqiang*; Wang, Yuanyuan*. Thermosensitive injectable in situ forming hydrogel incorporating anti-oxidative stress and anti-inflammatory nanoparticles for vital pulp therapy of pulpitis. Materials Today Bio, 2025, 31:101482. doi:10.1016/j.mtbio.2025.101482.

15）Ning, Xianling; Chen, Xi; Li, Ridong; Li, Yang; Lin, Zhiqiang*; Yin, Yuxin*. Identification of a novel cuproptosis inducer that induces ER stress and oxidative stress to trigger immunogenic cell death in tumors. Free Radical Biology and Medicine, 2025, 229:276-288. doi:10.1016/j.freeradbiomed.2025.01.042.

16）Liao Jun^#; Gong Lidong^#; Xu Q; Wang J; Yang Y; Zhang S; Dong J; Lin K; Liang Zichao; Sun Yuhua; Mu Yongxu; Chen Zhengjun; Lu Ying*; Zhang Qiang*; Lin Zhiqiang*. Revolutionizing Neurocare: Biomimetic Nanodelivery Via Cell Membranes. Advanced Materials, 2024, 36(26), 1-29. doi: 10.1002/adma.202402445

17）Zhu, Chuanda^#; Chen, Xi^#; Gong, Jingjing; Liu, Jiao; Gong, Lidong; Yang, Zeliang; Zhu, Zhenyu; Zhang, Qiang; Li, Tiancheng*; Liang, Ling*; Lin, Zhiqiang*. An elastase nanocomplex with metal cofactors for enhancement of target protein cleavage activity and synergistic antitumor effect. Chemical Engineering Journal, 2024, 485, 149902. doi: 10.1016/j.cej.2024.149902

18）Ridong Li*, Lidong Gong, Jiawei Sun, Zichao Liang, Jianan He, Junjie Huang, Xianling Ning, Huajie Song, Runtao Li, Qiang Zhang, Zhiqiang Lin*, Yuxin Yin*. Discovery of 2,4-diarylaminopyrimidine derivatives bearing sulfonamide moiety as novel FAK inhibitors. Bioorganic Chemistry. 2024;144:107134. doi:10.1016/j.bioorg.2024.107134

19） Xie Fei^#; Zhu Chuanda^#; Gong Lidong; Zhu Ningxin; Ma Qiang; Yang Yuanyuan; Zhao Xinrong; Qin Man; Lin Zhiqiang*; Wang Yuanyuan*. Engineering core-shell chromium nanozymes with inflammation-suppressing, ROS-scavenging and antibacterial properties for pulpitis treatment. Nanoscale 2023, 15 (34):13971-13986. doi: 10.1039/d3nr02930a

20）Yin Houqing; Wang Zequn; Wang Dan; Nuer Muhadaisi; Han Mengyuan; Ren Peng; Ma Shanwu; Lin Chutong; Chen Jingjing; Xian Haocheng; Ai Donemei; Li Xuejun; Ma Shaohua; Lin Zhiqiang*; Pan Yan*. TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulation. European Journal of Pharmacology. 2023, 955:175883. doi:10.1016/j.ejphar.2023.175883.

21）Gong, Lidong^#; Li, Ridong^#; Gong, Jingjing; Ning, Xianling; Sun, Jiawei; Ma, Qiang; Zhu, Chuanda; Yang, Yuanyuan; Lin, Kerui; Li, Yanglonghao; Zhang, Qiang; Li, Tiancheng*; Lin, Zhiqiang*. Discovery of a miniaturized PROTAC with potent activity and high selectivity. Bioorganic Chemistry. 2023, 136:106556. doi:10.1016/j.bioorg.2023.106556.

22）Sun, Yizhe^#; Gong, Lidong^#; Yin, Yue; Zhang, Lei; Zhang, Qiang; You, Fuping*; Lu, Dan*; Lin, Zhiqiang*. A gradient pH-sensitive polymer-based antiviral strategy via viroporin-induced membrane acidification. Advanced Materials, 2022, 34:1-12. doi: 10.1002/adma.202109580. (Selected as Cover)

23）Sun, Yizhe; Yin, Yue; Gong, Lidong; Liang, Zichao; Zhu, Chuanda; Ren, Caixia; Zheng, Nan; Zhang, Qiang; Liu, Haibin; Liu, Wei; You, Fuping; Lu, Dan*; Lin, Zhiqiang*. Manganese nanodepot augments host immune response against coronavirus. Nano Research, 2021;14(5):1260-1272. doi:10.1007/s12274-020-3243-5. (Selected as Journal Cover, Best Cover of Nano Research 2021, Top 10 Most Beautiful Covers of China's Outstanding Scientific and Technological Journals in 2021 by CAST)

24）Gong, Lidong; Xu, Pengcheng; Gong, Jingjing; Zhu, Chuanda; Di, Shiming; Zhang, Qiang; Lin, Zhiqiang*. Polymeric Nanoreactors with Chemically Tunable Redox Responsivity. ACS Applied Materials & Interfaces, 2022 Sep 7;14(35):40266-40275. doi:10.1021/acsami.2c07663. (Selected as Supplementary Cover)

25）Zhu, Chuanda^#; Ma, Qiang^#, Gong, Lidong, Di, Shiming; Gong, Jingjing; Wang, Yuanyuan; Xiao, Sheng; Zhang, Liang; Zhang, Qiang; Fu, Jijun*; Lu, Dan*; Lin, Zhiqiang*. Manganese-Based Multifunctional Nanoplatform for Dual-modal Imaging and Synergistic Therapy of Breast Cancer. Acta Biomaterialia, 2022;141:429-439. doi:10.1016/j.actbio.2022.01.019.

26）Ning, Xianlin^#; Qi, Hailong^#; Yuan, Yuyao; Li, Ridong; Wang, Yuanyuan; Lin, Zhiqiang*; Yin, Yuxin*. Identification of a new small molecule that initiates ferroptosis in cancer cells by inhibiting the system Xc- to deplete GSH. European Journal of Pharmacology, 2022;934:175304. doi:10.1016/j.ejphar.2022.175304.

27）Mei, Dong; Gong, Lidong; Zou, Yaru; Yang, Dan; Liu, Haibin; Liang, Yuguang; Sun, Ning; Zhao, Libo*; Zhang, Qiang*; Lin, Zhiqiang*. Platelet membrane-cloaked paclitaxel-nanocrystals augment postoperative chemotherapeutical efficacy. Journal of Controlled Release, 2020;324:341-353. doi:10.1016/j.jconrel.2020.05.016

28）Zhai, Zheng; Xu, Pengcheng; Yao, Jun; Li, Ridong; Gong, Lidong; Yin, Yuxin*; Lin, Zhiqiang*. Erythrocyte-mimicking paclitaxel nanoparticles for improving biodistributions of hydrophobic drugs to enhance antitumor efficacy. Drug Delivery, 2020, 27(1): 387-399. doi:10.1080/10717544.2020.1731862.

29）Chen, Mingyue^#; Xiao, Zekuan^#; Lei, Xueping^#; Li, Jiexia; Yu, Xiyong; Zhang, Jianye; Ye, Guodong; Guo, Yujuan; Mo, Guangquan; Li, Chuwen; Zhang, Yu; Zhang, Lingmin*; Lin, Zhiqiang*; Fu, Jijun*. Preparation, characterization and in vitro–in vivo evaluation of bortezomib supermolecular aggregation nanovehicles. Journal of Nanobiotechnology, 2020,18(57):1-12. doi:10.1186/s12951-020-00612-7.

30）Fu, Jijun^#; Li, Chuwen^#; Liu, Yang^#; Chen, Mingyue; Zhang, Qiang; Yu, Xiyong; Wu, Bo; Li, Jiexia; Du, Lingran; Dang, Yuanye; Wu, Dan; Wei, Minyan*; Lin, Zhiqiang*; Lei, Xueping*. The microneedles carrying cisplatin and IR820 to perform synergistic chemo-photodynamic therapy against breast cancer. Journal of Nanobiotechnology, 2020,18(146):1-15. doi:10.1186/s12951-020-00697-0.

31）Zhu, Ningxin; Wang, Dan; Xie, Fei; Qin, Man; Lin, Zhiqiang*; Wang, Yuanyuan*. Fabrication and Characterization of Calcium-Phosphate Lipid System for Potential Dental Application. Frontiers in Chemistry, 2020;8:161. doi:10.3389/fchem.2020.00161.

32）Lin, Zhiqiang*; Wan, Changrong; Li, Yang; Li, Ridong; Gong, Lidong; Su, Yue; Zhai, Zheng; Bai, Xinyu; Di, Shiming; Li, Zhao; Dong, Anjie; Zhang, Qiang*; Yin, Yuxin*. Glutathione-Priming Nanoreactors enable fluorophore shell transition for precision cancer imaging. ACS Applied Materials & Interfaces, 2019, 11(37): 33667-33675. doi:10.1021/acsami.9b11063. (Selected as Supplementary Cover)