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周源医学信息 ,研究员,博导

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主要学习及工作经历 2006.9-2010.7 首都师范大学生物科学专业 2010.7-2015.9 中国农业大学生物信息学专业 理学博士 2015.7-2017.9 北京大学医学部基础医学院医学信息学系 博士后 2017.9-至今 北京大学医学部基础医学院医学信息学系 副研究员
研究方向 转录组、表观转录组与分子网络的生物信息学分析
基金来源 1、国家自然科学基金青年项目,3180080426,“基于上下文的RNA甲基化(m6A)谱的比较分析”,2019/01-2021/12,25万元,获批,主持。 2、北京大学医学部启动基金项目,BMU2017YJ004,“表观转录组计算分析平台的建立”,2017/09-2019/12,50万元,在研,主持。
代表论文 1、 Jianwei Li*, Xiaofen Han, Yanping Wan, Shan Zhang, Yingshu Zhao, Rui Fan, Qinghua Cui, Yuan Zhou*. TAM 2.0: tool for microRNA set analysis. Nucl Acids Res, 2018, 2018,46(W1):W180-W185. 2、Chunmei Cui#, Weili Yang#, Jiangcheng Shi, Yong Zhou, Jichun Yang, Qinghua Cui*, Yuan Zhou*. Identification and analysis of human sex-biased microRNAs. Genomics, Proteomics Bioinformatics, 2018, 16(3): 200-211. 3、Yuan Zhou*, Qinghua Cui*. Comparative Analysis of Human Genes Frequently and Occasionally Regulated by m6A Modification. Genomics, Proteomics Bioinformatics, 2018, 16(2):127-135. 4、 Wei Ma#, Ji Chen#, Yuhong Meng#, Jichun Yang, Qinghua Cui*, Yuan Zhou*. Metformin alters gut microbiota of healthy mice: implication for its potential role in gut microbiota homeostasis. Front Microbiol, 2018, 9:1336. 5、Jun Guo#, Yuan Zhou#, Yafen Cheng#, Weiwei Fang#, Gang Hu, Jie Wei, Yajun Lin, Yong Man, Lixin Guo, Mingxiao Sun*, Qinghua Cui*, Jian Li*. Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice. Cell Physiol Biochem, 2018, 45(4): 1487-1505. 6、Wenjing Xu#, Yuan Zhou#, Guoheng Xu*, Bin Geng*, Qinghua Cui*. Transcriptome analysis reveals non-identical microRNA profiles between arterial and venous plasma. Oncotarget, 2017, 8(17):28471-28480. 7、Shiping Yang, Hong Li, Fei He, Yuan Zhou*, Ziding Zhang*. Critical assessment and performance improvement of plant-pathogen protein-protein interaction prediction methods. Brief Bioinform, 2017, in press, doi: 10.1093/bib/bbx123. 8、Hong Li, Yuan Zhou*, Ziding Zhang*. Network Analysis Reveals a Common Host-Pathogen Interaction Pattern in Arabidopsis Immune Responses. Front Plant Sci, 2017, 8:893. 9、Xinhua Liu, Pan Zeng, Qinghua Cui*, Yuan Zhou*. Comparative analysis of genes frequently regulated by drugs based on connectivity map transcriptome data. PLoS ONE, 2017, 12(6):e0179037. 10、Yuan Zhou*, Pan Zeng, Yan-Hui Li, Ziding Zhang, Qinghua Cui*. SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features. Nucl Acids Res, 2016,44(10):e91.

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