2002.9-2006.7 兰州大学 学士

2006.9-2012.8 中国科学院生物物理研究所 博士

2012.8-2016.7 美国布鲁克海文国家实验室 博士后

2016.7-2020.8 美国Van Andel研究所 高级研究科学家

2020.9至今 北京大学基础医学院 研究员

疾病相关膜蛋白的结构与功能研究

真菌药物靶点的结构和功能研究及相关药物研发

1. 国家自然科学基金面上项目

2. 优秀青年科学基金项目（海外）

1. Zhao P, Zhao C, Chen D, Yun C, Li H*, Bai L*. Structure and activation mechanism of the hexameric plasma membrane H+-ATPase. Nat Commun. 2021 Nov 8;12(1):6439.

2. Bai L#*, Jain BK#, You Q#, Duan HD, Takar M, Graham TR*, Li H*. Structural basis of the P4B ATPase lipid flippase activity. Nat Commun. 2021 Oct 13;12(1):5963.

3. Bai L#*, You Q#, Jain BK#, Duan HD, Kovach A, Graham TR, Li H*. Transport mechanism of P4 ATPase phosphatidylcholine flippases. Elife. 2020 Dec 15;9:e62163.

4. Bai L*, You Q, Feng X, Kovach A, Li H*. Structure of the ER membrane complex, a transmembrane-domain insertase. Nature. 2020 Aug;584(7821):475-478.

5. Bai L*, Kovach A, You Q, Hsu HC, Zhao G, Li H*. Atomic structure of the eukaryotic lipid flippase Drs2p-Cdc50p. Nat Commun. 2019; 10:4142

6. Bai L, Kovach A, You Q, Kenny A, Li H*. Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex. Nat Struct Mol Biol. 2019. 26:704-711

7. Bai L, Wang T, Zhao G, Kovach A, Li H*. The atomic structure of a eukaryotic oligosaccharyl transferase complex. Nature. 2018; doi:10.1038/nature25755

8. Santos RLA#, Bai L#, Singh PK#, Murakami N#, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H*, Azzi J*, Lin G*. Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nat Commun. 2017. 8(1):1692.

9. Yuan Z#, Riera A#, Bai L#, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B*, Speck C*, Li H*. Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat Struct Mol Biol. 2017. 24(3):316-324.

10. Bai L#, Hu K#, Wang T#, Jastrab JB, Darwin KH*, Li H*. Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2016. 113(14):E1983-92.