2001.9-2005.6    北京师范大学生命科学专业  学士

2005.7-2007.8    中国科学院遗传与发育生物学研究所  科研助理

2007.9-2012.6    中国科学院遗传与发育生物学研究所生物信息学专业  博士

2012.7-2013.2    中国科学院遗传与发育生物学研究所  科研助理

2013.3-2015.6    美国哈佛大学丹娜-法伯癌症研究所  博士后

2015.7-2020.6    美国哈佛大学丹娜-法伯癌症研究所  副研究员

2020.7-2021.3    美国哈佛大学丹娜-法伯癌症研究所  研究员

2021.4-今        北京大学基础医学院精准医疗多组学研究中心  研究员

2021.7-今        北京大学肿瘤医院  研究员

AI驱动的基因组学

1. KDM5基因家族在胃癌中的作用机制、小分子抑制剂开发及联合免疫治疗的研究（北京大学临床医学+X青年专项） 2022年1月-12月 校级 30万 主持

2. 腰椎间盘突出症中医方案效应机制研究（国家重点研发计划） 2021年12月-2023年12月 国家级 30万 课题骨干

1. Wu HJ, Temko D, Maliga Z, Moreira A, Sei E, Minussi DC, Dean J, Lee C, Xu Q, Hochart G, Jacobson C, Yapp C, Schapiro D, Sorger P, Seeley EH, Navin N, Downey RJ, Michor F. Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients. Cell Genomics. 2022;2(8):100165.

2. Wu HJ, Landshammer A, Stamenova EK, Bolondi A, Kretzmer H, Meissner A, Michor F. Topological isolation of developmental regulators in mammalian genomes. Nat Commun. 2021;12(1):4897.

3. Wu HJ, Michor F. A computational strategy to adjust for copy number in tumor Hi-C data. Bioinformatics. 2016;32(24):3695-3701.

4. Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K. KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance. Cancer Cell. 2018;34(6):939-953 e9. (Co-first author)

5. Shu SK, Wu HJ, Ge JY, Zeid R, Harris IS, Jovanovic B, Murphy K, Wang BB, Qiu XT, Endress JE, Reyes J, Lim K, Font-Tello A, Syamala S, Xiao TF, Chilamakuri CSR, Papachristou EK, D'Santos C, Anand J, Hinohara K, Li W, McDonald TO, Luoma A, Modiste RJ, Nguyen QD, Michel B, Cejas P, Kadoch C, Jaffe JD, Wucherpfennig KW, Qi J, Liu XS, Long H, Brown M, Carroll JS, Brugge JS, Bradner J, Michor F, Polyak K. Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Mol Cell. 2020;78(6):1096-+. (Co-first author)

6. Han L, Wu HJ, Zhu HY, Kim KY, Marjani SL, Riester M, Euskirchen G, Zi X, Yang J, Han J, Snyder M, Park IH, Irizarry R, Weissman SM, Michor F, Fan R, Pan XH. Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells. Nucleic Acids Res. 2017;45(10). (Co-first author)

7. Zhang NQ, Wu HJ, Zhang WW, Wang J, Wu H, Zheng XQ. Predicting tumor purity from methylation microarray data. Bioinformatics. 2015;31(21):3401-3405. (Co-first author)

8. Zheng XQ, Zhao Q, Wu HJ, Li W, Wang HY, Meyer CA, Qin QA, Xu H, Zang CZ, Jiang P, Li FQ, Hou YQ, He JX, Wang J, Wang J, Zhang P, Zhang Y, Liu XS. MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes. Genome Biol. 2014;15(8). (Co-first author)

9. Wu HJ, Wang ZM, Wang M, Wang XJ. Widespread Long Noncoding RNAs as Endogenous Target Mimics for MicroRNAs in Plants. Plant Physiol. 2013;161(4):1875-1884.

10. Wu HJ, Ma YK, Chen T, Wang M, Wang XJ. PsRobot: a web-based plant small RNA meta-analysis toolbox. Nucleic Acids Res. 2012;40(W1):W22-W28.