2009.09-2013.07    中央民族大学 生物科学专业 本科生

2013.08-2018.09    北京大学 医学生物化学与分子生物学专业 硕博生

2018.10-2022.09    北京大学 药学专业 博士后

2022.10至今       北京大学 中西医结合基础专业 新体制助理教授/副研究员 

2022年，北京大学基础医学院青年岗位能手

2021年，北京大学“拜耳”博士后

2021年，北京大学医学部优秀博士后

2019年，北京大学优秀博士学位论文

2018年，北京大学博雅博士后

2018年，北京大学优秀毕业生及三好学生

2017年，北京大学医学研究生特等（精勤厚道医学生）奖学金

2014年，国家奖学金

肿瘤表观遗传调控及干预策略。揭示肿瘤等疾病发生发展的表观遗传及基因转录调控机制，阐释中药及其活性成分发挥抗肿瘤等作用的分子机制，探索临床相关疾病治疗的中西医干预策略。

1. 2023年1月—2026年12月，国家自然科学基金面上项目，国家级，55万，主持，在研；

2. 2023年1月—2025年12月，北京市自然科学基金面上项目，省部级，20万，主持，在研；

3. 2021年1月—2022年12月，国家自然科学基金青年项目，国家级，16万，主持，结题；

4. 2019年5月—2022年9月，中国博士后基金面上项目，省部级，8万，主持，结题。

1. Rui-Yuan Pan*, Lin He*, Jing Zhang, Xinhua Liu, Yajin Liao, Yuhan Yan, Ju Gao, Qianqian Li, Yang Liao, Jinbo Cheng, Qu Xing, Fangxia Guan, Xinglong Wang, Jie Zhang, Luyang Sun#, and Zengqiang Yuan# (2022). Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease. Cell Metabolism 34(4):634-648.

2. Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Luyang Sun#, and Yongfeng Shang# (2018). Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Research 28:934-951.

3. Lin He*, Ruorong Yan*, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, and Luyang Sun# (2021). SCF^JFK Is Functionally Linked to Obesity and Metabolic Syndrome. EMBO Reports 22(7): e52036.

4. Meng-Lei Hu, Qian-Zan Liao, Bo-Tong Liu, Xiao-Yi Wang, Kai Sun Chun-Shui Pan, Li Yan, Xin-Mei Huo, Xian-Qun Zhen, Yuan Wang, Li-Jun Zhong, Jian Liu, Lin He#, and Jing-Yan Han# (2023). Xihuang pill ameliorates colitis in mice through improving mucosal barrier injury and inhibiting inflammatory cell filtration by network regulation. Journal of Ethnopharmacology 319 (Pt 1): 117098.

5. Ziran Yang*, Xuehong Zhou*, Enrun Zheng, Yizhou Wang, Xinhua Liu, Yue Wang Yanpu Wang, Zhaofei Liu, Fei Pei, Yue Zhang, Jie Ren, Yunchao Huang, Lu Xia, Sudun Guan, Sen Qin, Feiya Suo, Jie Shi, Lijing Wang, Lin He#, and Luyang Sun# (2021). JFK Is a Hypoxia-inducible Gene that Functions to Promote Breast Carcinogenesis. Frontiers in Cell and Developmental Biology 9: 686737.

6. Xujun Liu, Wenzhe Si, Lin He, Jianguo Yang, Yani Peng, Jie Ren, Xiaoping Liu, Tong Jin, Huajing Yu, Zihan Zhang, Xiao Chen, Wenting Zhang, Lu Xia, Yunchao Huang, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Xiaohan Yang, Haixia Li, Jing Liang, Luyang Sun#, and Yongfeng Shang# (2021). The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry. Signal Transduction and Targeted Therapy 6(1): 375.

7. Xiaoping Liu*, Bosen Xu*, Jianguo Yang, Lin He, Zihan Zhang, Xiao Cheng, Huajing Yu, Xujun Liu, Tong Jin, Yani Peng, Yunchao Huang, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Shumeng Liu, Lin Shan, Xiaohan Yang, Luyang Sun, Jing Liang, Yu Zhang#, and Yongfeng Shang# (2021). UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1. Molecular Cell 81(14):2960-2974.

8. Lifang Li, Xinhua Liu, Lin He, Jianguo Yang, Fei Pei, Wanjin Li, Shumeng Liu, Zhe Chen, Guojia Xie, Bosen Xu, Xia Ting, Zihan Zhang, Tong Jin, Xujun Liu, Wenting Zhang, Shuai Yuan, Ziran Yang, Chongyang Wu, Yu Zhang, Xiaohan Yang, Xia Yi, Jing Liang, Yongfeng Shang, and Luyang Sun# (2017). ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nature Communications 8: 691-707.

9. Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, Guojia Xie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun#, and Yongfeng Shang# (2015). SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes & Development 29: 672-685.

10. Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun#, and Yongfeng Shang# (2014). JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. Plos Biology 12(3): e1001819.