主要学习及工作经历

2003.9-2007.7    中国农业大学生物科学专业本科生

2009.8-2015.5    美国哥伦比亚大学营养与代谢生物学博士研究生

2015.6-2016.7    美国哥伦比亚大学儿科博士后

2016.8-2018.6    美国哥伦比亚大学内分泌专业博士后

2018.7-2022.8    美国哥伦比亚大学内分泌专业助理研究员

2022.9-2023.7    美国伊坎西奈山医学院代谢研究所助理教授

2023.8-              北京大学医学部基础医学院心血管研究所

主要学术任职

2014-2015 Member, International Society for Stem Cell Research

2016-2017             Member, The Obesity Society

2015-                   Member, The American Association for the Advancement of Science

2022-                     Member, Chinese American Diabetes Association

2023-                     Member, American Diabetes Association

2023-                     Member, Society of Chinese Bioscientists in America

2024-   中国生化与细胞协会脂代谢分会青年委员

2024-   中国生理学会内分泌代谢分会委员

获奖情况

2019 Regeneron scholarship for the 2019 Cold Spring Harbor Laboratory course “Computational Genomics”

2014 Keystone Symposia scholarship “A Multisystems Perspective”
2012 Travel award of the 2nd International Hyperphagia Conference
2012 Travel award of the NIDDK “Body Fat Disorders” Conference
2011 Marija Chouinard Awards for Excellence in Research, Institute of Human Nutrition, Columbia University (Highest award for IHN student) 

研究方向 长期致力于能量代谢稳态调控机制研究，聚焦肥胖、糖尿病、心血管疾病及衰老相关代谢紊乱的分子机制，取得以下原创性成果：（1）首次建立人类遗传性肥胖症的人源干细胞模型，并系统阐明了一系列遗传性肥胖症的致病机理(JCI 2015,2021; JCI Insight 2019; Stem Cell reports 2017)；（2）系统鉴定了参与肝糖代谢调控的转录因子，进而发现了新的2型糖尿病 (TOX4) 和非酒精性脂肪肝炎 (PU.1) 的致病因子(Cell metabolism 2022; Journal of Hepatology 2020; Diabetes 2019); （3）揭示IgG作为肥胖和衰老的共同驱动因子，通过介导脂肪组织胰岛素抵抗、慢性炎症及代谢功能失调加速病理进程(Cell Metabolism 2024, 2025)。先后在Cell, Cell Metabolism, Journal of Hepatology，JCI等期刊发表论文20余篇，总被引2400余次。研究成果获JCI同期专题评述，被Nature Aging、Nature Reviews Endocrinology列为研究亮点，其中IgG调控代谢衰老的突破性发现入选Cell Metabolism "解码肥胖复杂系统" 特刊（2024年世界肥胖日纪念专刊），并荣膺"2024年度中国肥胖研究十大成果"。 目前实验室以TOX4和IgG为切入点，整合单细胞转录组学、空间代谢组学、高通量功能基因组学及人诱导多能干细胞（iPSC）模型，重点研究：①能量代谢稳态的神经调控生理及病生理机制；②代谢稳态失衡在衰老及肥胖相关疾病中的病理作用机制；③外周组织糖脂代谢时空特异性调控网络。相关研究为代谢性疾病的精准干预提供新靶点。

基金来源

5K01DK123199                               09/04/2019-08/31/2024                        National Institute of Health/NIDDK

Role: PI

Pilot & Feasibility grant                   5/15/2023-5/14/2024                              Einstein-Mount Sinai DRC

Role: PI

国家基金委海外优秀青年人才基金  2022-2025  主持

面上基金  2025.1-2028.12  主持

科技部四大慢病重点研发子课题负责人 2026.3-2030.2   主持

 

 

 

代表论文

1. Yu L, Yang Y, Gong Z, Wang Q, Du Y, Zhou Q, Xiao Y, Zahr T, Wang Z, Yu Z, Yang K, Geng J, Fried SK, Li J, Haeusler RA, Leong K, Bai L, Wu Y, Sun L, Wang P, Zhu B, Wang L*, Li Qiang*. FcRn-dependent IgG Accumulation in Adipose Tissue Unmasks Obesity Pathophysiology. Cell Metab. 2025 Mar 4;37(3):656-672.e7. (*Co-corresponding author)

2. Yu L, Wan Q, Liu Q, Fan Y, Zhou Q, Skowronski A. A, Wang S, Shao Z, Liao C, Lei Ding L, Kennedy B, Zha S, Que J, LeDuc CA, Sun L, Wang L*, Li Qiang*. IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline. Cell Metab.2024 April 2; 36:1-14. (*共同通讯）

3. Wang L*, Yu J, Zhou Q, Wang X, Mukhanova M, Du W, Sun L, Pajvani UB, Accili D.  TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver. Cell Metab. 2022 Jan 4;34(1):158-170. (*共同通讯）

4. Ma F, Longo M, Meroni M, Bhattacharya D, Paolini E, Mughal S, Hussain S, Anand SK, Gupta N, Zhu Y, Navarro-Corcuera A, Li K, Prakash S, Cogliati B, Wang S, Huang X, Wang X, Yurdagul A Jr, Rom O, Wang L, Fried SK, Dongiovanni P, Friedman SL, Cai B. EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis. Cell Metab. 2025 Feb 20:S1550-4131(25)00019-1. 

5. Carty J, Devarakonda K, O'Connor R, Krek A, Espinoza D,  Jimenez-Gonzalez M, Alvarsson A, Hampton R, Li R, Petri S, Shtekler A, Rajbhandari A, Conner K, Bayne M, Garibay D, Martin J, Lehmann V, Wang L, Beaumont K, Kurland I, Yuan G, Kenny P, Stanley S. Amygdala-liver signalling orchestrates glycaemic responses to stress. Nature. 2025 Oct;646(8085):697-706

6. Li J, Jiang M, Wang Q, Zheng Z, Shen J, Li J, Xiong M, Zheng Y, Lu X, Cai Y, Fan Y, Geng L, Ji Q, …..Wang L*, …..Pei G, Liu GH. The X-Age Project to construct a Chinese aging clock. Nat Aging. 2025 Sep;5(9):1669-1685. (*共同通讯)

7. Aaron N, Kraakman MJ, Zhou Q, Liu Q, Costa S, Yang J, Liu L, Yu L, Wang L, He Y, Fan L, Hirakawa H, Ding L, Lo J, Wang W, Zhao B, Guo E, Sun L, Rosen CJ, Qiang L. Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. eLife. 2021 Jun 22;10:e69209.

8. Wang L*, Liu Y, Stratigopoulos G, Panigrahi SK, Sui L, Zhang Y, LeDuc CA, Glover HJ, De Rosa MC, Burnett LC, Williams DJ, Shang L, Goland R, Tsang SH, Wardlaw SL, Egli D, Zheng D, Doege CA, Leibel RL. Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons. J Clin Invest. 2021 Apr 15;131(8):e146287. (*Co-corresponding author, Cover story)

9. Liu Q*, Yu J*, Wang L*, Tang Y, Zhou Q, Ji S, Wang Y, Santos L, Haeusler RA, Que J, Rajbhandari P, Lei X, Valenti L, Pajvani UB, Qin J, Qiang L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. J Hepatol. 2020 Mar:S0168-8278(20)30124-0. (*: co-first author)

10. Wang L, Liu Q, Kitamoto T, Hou J, Qin J, Accili D. Identification of insulin-responsive transcription factors that regulate glucose production by hepatocytes. Diabetes. 2019 Jun; 68(6): 1156-1167.

11. Wang L, De Solis AJ, Goffer Y, Kathryn E. Birkenbach KE, Engle SE, Tanis R , Levenson JM, Li X, Rausch R, Purohit M, Lee J, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight. 2019 Feb; 4(3):e123337.

12. Wang L, Sui L, Panigrahi SK, Meece K, Doege CA, Wardlaw SL, Egli D, Leibel RL. PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons. Stem Cell Reports. 2017 Feb; 14;8(2):264-277.

13. Burnett LC, LeDuc CA, Sulsona CR, Paull D, Rausch R, Eddiry S, Carli JF, Morabito MV, Skowronski AA, Hubner G, Zimmer M, Wang L, Day R, Levy B, Fennoy I, Dubern B, Poitou C, Clement K, Butler MG, Rosenbaum M, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. J Clin Invest. 2017 Jan; 127(1):293-305.

14. Wang L, Egli D, Leibel RL. Efficient generation of hypothalamic neurons from human pluripotent stem cells. Curr Protoc Hum Genet. 2016 Jul; 90:21.5.1-21.5.14.

15. Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest. 2015 Feb;125(2):796-808.