主要学习及工作经历

2003.9-2007.7    中国农业大学生物科学专业本科生

2007.8-2009.5    美国阿肯色大学医学院生理与生物物理研究生

2009.8-2015.5    美国哥伦比亚大学营养与代谢生物学博士研究生

2015.6-2016.7    美国哥伦比亚大学儿科博士后

2016.8-2018.6    美国哥伦比亚大学内分泌专业博士后

2018.7-2022.8    美国哥伦比亚大学内分泌专业助理研究员

2022.9-2023.7    美国纽约西奈山医学院代谢研究所助理教授

2023.8-              北京大学医学部基础医学院心血管研究所

主要学术任职

2014-2015 Member, International Society for Stem Cell Research

2016-2017             Member, The Obesity Society

2015-                   Member, The American Association for the Advancement of Science

2022-                     Member, Chinese American Diabetes Association

2023-                     Member, American Diabetes Association

2023-                     Member, Society of Chinese Bioscientists in America

获奖情况

2019 Regeneron scholarship for the 2019 Cold Spring Harbor Laboratory course “Computational Genomics”

2014 Keystone Symposia scholarship “A Multisystems Perspective”
2012 Travel award of the 2nd International Hyperphagia Conference
2012 Travel award of the NIDDK “Body Fat Disorders” Conference
2011 Marija Chouinard Awards for Excellence in Research, Institute of Human Nutrition, Columbia University (Highest award for IHN student) 

研究方向

肝脏糖脂代谢的转录调控

本人实验室聚焦代谢疾病的基础研究，揭示糖脂代谢的新的转录调控机制和发现代谢器官间交流的新的调节因子/通路，进一步探索其在糖尿病，脂肪肝及心血管疾病病理发生过程中的致病机理，为预防和治疗相关的代谢疾病提供理论依据。

基金来源

5K01DK123199                               09/04/2019-08/31/2024                        National Institute of Health/NIDDK

Role: PI

Pilot & Feasibility grant                   5/15/2023-5/14/2024                              Einstein-Mount Sinai DRC

Role: PI

 

国家基金委人才基金

 

 

 

代表论文

1. Wang L*, Yu J, Zhou Q, Wang X, Mukhanova M, Du W, Sun L, Pajvani UB, Accili D.  TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver. Cell Metab. 2022 Jan 4;34(1):158-170. (*Co-corresponding author)

 

2. Aaron N, Kraakman MJ, Zhou Q, Liu Q, Costa S, Yang J, Liu L, Yu L, Wang L, He Y, Fan L, Hirakawa H, Ding L, Lo J, Wang W, Zhao B, Guo E, Sun L, Rosen CJ, Qiang L. Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. eLife. 2021 Jun 22;10:e69209.

 

3. Wang L*, Liu Y, Stratigopoulos G, Panigrahi SK, Sui L, Zhang Y, LeDuc CA, Glover HJ, De Rosa MC, Burnett LC, Williams DJ, Shang L, Goland R, Tsang SH, Wardlaw SL, Egli D, Zheng D, Doege CA, Leibel RL. Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons. J Clin Invest. 2021 Apr 15;131(8):e146287. (*Co-corresponding author, Cover story)

 

4. Liu Q*, Yu J*, Wang L*, Tang Y, Zhou Q, Ji S, Wang Y, Santos L, Haeusler RA, Que J, Rajbhandari P, Lei X, Valenti L, Pajvani UB, Qin J, Qiang L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. J Hepatol. 2020 Mar:S0168-8278(20)30124-0. (*: co-first author)

 

5. Wang L, Liu Q, Kitamoto T, Hou J, Qin J, Accili D. Identification of insulin-responsive transcription factors that regulate glucose production by hepatocytes. Diabetes. 2019 Jun; 68(6): 1156-1167.

 

6. Wang L, De Solis AJ, Goffer Y, Kathryn E. Birkenbach KE, Engle SE, Tanis R , Levenson JM, Li X, Rausch R, Purohit M, Lee J, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight. 2019 Feb; 4(3):e123337.

 

7. Wang L, Sui L, Panigrahi SK, Meece K, Doege CA, Wardlaw SL, Egli D, Leibel RL. PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons. Stem Cell Reports. 2017 Feb; 14;8(2):264-277.

 

8. Burnett LC, LeDuc CA, Sulsona CR, Paull D, Rausch R, Eddiry S, Carli JF, Morabito MV, Skowronski AA, Hubner G, Zimmer M, Wang L, Day R, Levy B, Fennoy I, Dubern B, Poitou C, Clement K, Butler MG, Rosenbaum M, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. J Clin Invest. 2017 Jan; 127(1):293-305.

 

9. Wang L, Egli D, Leibel RL. Efficient generation of hypothalamic neurons from human pluripotent stem cells. Curr Protoc Hum Genet. 2016 Jul; 90:21.5.1-21.5.14.

 

10. Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest. 2015 Feb;125(2):796-808.